Added 14 hours ago Drug news

The European commission approves expanded use of Janssen’s Stelara® (ustekinumab) for the treatment of paediatric patients with moderate to severe plaque psoriasis

The European commission approves expanded use of Janssen’s Stelara^® (ustekinumab) for the treatment of paediatric patients with moderate to severe plaque psoriasis.

Added 22 days ago Drug news

The National Institute for Health and Care Excellence refuses recommendation for Waylivra to treat Familial Chylomicronaemia Syndrome.- Akcea Therapeutics

The National Institute for Health and Care Excellence (NICE) has issued an Evaluation Consultation Document (ECD), refusing Waylivra (volanesorsen) as...

Added 1 month ago Drug news

Lonafarnib filed with FDA for rolling review in progeria.- Eiger Biopharma

Eiger BioPharmaceuticals announced that it has initiated submission of a New Drug Application (NDA) for Lonafarnib for the treatment of...

Cannabis-based medicinal products

This guideline covers prescribing of cannabis-based medicinal products for people with intractable nausea and vomiting, chronic pain, spasticity and severe treatment-resistant epilepsy.

Added 1 month ago

Fever in under 5s: assessment and initial management

This guideline covers the assessment and early management of fever with no obvious cause in children aged under 5. It aims to improve clinical assessment and help healthcare professionals diagnose serious illness among young children...

Added 6 years ago

Epilepsies: diagnosis and management

The guideline covers diagnosing, treating and managing epilepsy and seizures in children, young people and adults in primary and secondary care.

Added 8 years ago

Summary of recommendations for the management of infantile seizures: Task Force Report for the ILAE Commission of Pediatrics.

This report provides a comprehensive foundation of an approach to infants with seizures, while identifying where there are inadequate data to support recommended practice, and where further data collection is needed to address these deficits.

Added 20 days ago

Attention-deficit hyperactivity disorder: treatment discontinuation in adolescents and young adults.

Aims: To determine the prevalence of methylphenidate, dexamfetamine and atomoxetine prescribing and treatment discontinuation in adolescents and young adults.

Added 21 days ago

Non-pharmacological interventions for cognitive difficulties in ADHD: A systematic review and meta-analysis.

Attention deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in children and is associated with significant risk of educational failure, interpersonal problems, mental illness, and delinquency.

Added 21 days ago

Study of Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy

The primary objective of the study is to examine the clinical efficacy of nusinersen administered intrathecally at higher doses to participants with spinal muscular atrophy (SMA).

Added 4 months ago

A Study of Ocrelizumab in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis

This 2-year study will evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamic (PD) effects of ocrelizumab in children and adolescents ages >/= 10 to < 18 years with relapsing-remitting multiple sclerosis (RRMS).

Added 3 months ago

A Dose-finding Study of Inhaled OligoG vs Placebo in Patients With Cystic Fibrosis (SMR3372)

Randomized, double blind, placebo controlled study. The study has two parts:
Dose-finding part, followed by longer term follow-up (6 months)

Added 3 months ago