Added 15 days ago Drug news

Application for Fintepla in Dravet Syndrome rejected by FDA

The FDA has refused to fully review the marketing application for Fintepla (low-dose fenfluramine) from Zogenix, developed to treat seizures...

Added 1 month ago Drug news

Two Phase III studies of VX 445, tezacaftor and ivacaftor meet primary endpoint in cystic fibrosis

Vertex has announced that treatment with the triple combination of the next-generation corrector VX 445, tezacaftor and ivacaftor resulted in...

Added 1 month ago Drug news

Conditional approval of Waylivra to treat genetically confirmed familial chylomicronemia syndrome

Akcea Therapeutics, Inc. an affiliate of Ionis Pharmaceuticals, Inc., and Ionis Pharmaceuticals, Inc. announced that the Committee for Medicinal Products...

Lyme disease

This guideline covers diagnosing and managing Lyme disease. It aims to raise awareness of when Lyme disease should be suspected and ensure that people have prompt and consistent diagnosis and treatment.

Added 10 months ago

Epilepsies: diagnosis and management

The guideline covers diagnosing, treating and managing epilepsy and seizures in children, young people and adults in primary and secondary care.

Added 7 years ago

Otitis media (acute): antimicrobial prescribing

This guideline sets out an antimicrobial prescribing strategy for acute otitis media (ear infection). It aims to limit antibiotic use and reduce antimicrobial resistance.

Added 10 months ago

Disease trajectories in childhood atopic dermatitis: an update and practitioner's guide.

Background: Atopic dermatitis (AD) is a heterogeneous disease with a multifactorial aetiology and complex pathophysiology. This heterogeneity translates into different trajectories of disease progression with respect to...

Added 16 days ago

Increased salivary fluid flow in children with newly diagnosed allergic rhinitis.

Objectives: The pathogenesis of allergic rhinitis (AR) may involve dysregulation of the autonomic nervous system (ANS). Salivary fluid flow and salivary alpha-amylase (sAA) secretion are able to reflect the activity of...

Added 17 days ago

Migraine in childhood: an organic, biobehavioral, or psychosomatic disorder?

Migraine is one of the most frequent complaints in children and adolescents and it can have a significant impact on quality of life. There are several factors underlying the onset and the maintenance of this disorder and there...

Added 21 days ago

JAK1 Inhibitor With Medicated Topical Therapy in Adolescents With Atopic Dermatitis (JADE TEEN)

This is a randomized, double blind, placebo controlled, parallel group, Phase 3 study to evaluate the efficacy and safety of PF 04965842 in adolescent participants 12 to <18 years of age with moderate to severe AD

Added 1 month ago

A Study to Evaluate Risankizumab in Adult and Adolescent Subjects With Moderate to Severe Atopic Dermatitis

The purpose of this study is to assess the safety and efficacy of risankizumab for the treatment of moderate to severe atopic dermatitis (AD) in adult and adolescent subjects.

Added 1 month ago

Efficacy and Safety Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis

This is a Phase 3, multicenter, randomized, placebo-controlled, double-blind study of the efficacy and safety of apremilast (CC-10004) in pediatric subjects with moderate to severe plaque psoriasis.

Added 1 month ago