1,119 Results

Erenumab for episodic migraine prophylaxis.

Introduction: This paper reviews placebo-controlled randomized double-blind studies with erenumab for the prevention of migraine. Erenumab is a fully human monoclonal antibody (mAb), which specifically blocks the calcitonin...

Symptoms related to the visual system in migraine.

Migraine is a common headache disorder characterized by often-severe headaches that may be preceded or accompanied by a variety of visual symptoms. Although a typical migraine aura is not difficult to diagnose, patients with...

Transient Neurologic Dysfunction in Migraine.

Transient disturbances in neurologic function are disturbing features of migraine attacks. Aura types include binocular visual, hemi-sensory, language and unilateral motor symptoms.

Surgical Management of Migraine Headaches: A Systematic Review and Meta-analysis.

Background: The aim of the present study was to systematically review and analyze the available evidence on the role of surgery in improving outcomes in patients with migraine headaches.

The treatment efficacy of galcanezumab for migraine: A meta-analysis of randomized controlled trials.

The treatment efficacy of galcanezumab for migraine remained controversial. We conducted a systematic review and meta-analysis to explore the influence of galcanezumab versus placebo on the treatment of migraine.

Early Onset of Efficacy With Fremanezumab for the Preventive Treatment of Chronic Migraine.

Objective: To assess the onset of efficacy for fremanezumab in chronic migraine by evaluating pain‐related clinical measures at different time points.

Deep Brain Stimulation for Freezing of Gait in Parkinson's Disease With Early Motor Complications.

Objective: Secondary analysis to assess whether DBS affects these symptoms within a large randomized controlled trial comparing DBS of the STN combined with best medical treatment and best medical treatment alone in patients...

Natalizumab promotes activation and pro-inflammatory differentiation of peripheral B cells in multiple sclerosis patients.

Background: In the past, multiple sclerosis (MS) medications have been primarily designed to modulate T cell properties. Based on the emerging concept that B cells are equally important for the propagation of MS, we compared...

Interleukin 18 Polymorphisms and its serum level in Patients with Multiple Sclerosis.

Propose: To determine the serum level of interleukin-18 (IL-18) as well as gene polymorphisms of IL-18 (rs1946518, rs360719, and rs187238).

Long-range connections are more severely damaged and relevant for cognition in multiple sclerosis.

An efficient network such as the human brain features a combination of global integration of information, driven by long-range connections, and local processing involving short-range connections.