Data from multiple sources - Curated by Toby Galbraith - Last updated 06 June 2017

Latest news articles

Added 8 hours ago Drug news

APOLLO phase III study of ALN TTR02 (patisiran) in hereditary ATTR amyloidosis with polyneuropathy meets primary endpoints.- Sanofi Genzyme + Alnylam Pharmaceuticals.

Sanofi Genzyme and Alnylam Pharmaceuticals announced that the APOLLO Phase III study of ALN TTR02 (patisiran), for patients with hereditary...

Added 5 days ago Drug news

CHMP adopts negative opinion for its Type II extension application for Raxone (idebenone) in Duchenne muscular dystrophy .- Santhera Pharmaceuticals

Santhera Pharmaceuticals) announces that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has...

Added 8 days ago Drug news

Phase III SAHARA study success for SHP 616 Liquid (subcutaneously administered C1 esterase inhibitor [human] Liquid for Injection) to treat Hereditary Angioedema.-Shire plc.

Shire plc announces positive topline Phase III results for the SAHARA study, a global, multi-center, randomized, double-blind, placebo-controlled, partial crossover...

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Learning Zones

An Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Cystic Fibrosis

View disease awareness information, treatment options and European Cystic Fibrosis Society best practice guidelines.

Visit Cystic Fibrosis

Chronic Obstructive Pulmonary Disease (COPD)

View highlights from recent congresses presented in new expert videos with leading physicians.

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Visit Chronic Obstructive Pulmonary Disease (COPD)

Oral Anticoagulation Reversal

Experts discuss the use of non-vitamin K oral anticoagulants in the treatment and prevention of stroke, deep vein thrombosis and pulmonary embolism in atrial fibrillation patients.

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Canadian Guidelines for the Management of Plaque Psoriasis 2009

Since the publication of the 2009 Canadian Guidelines for the Management of Plaque Psoriasis, significant advances have been made in determining the role of T cells in inflammatory and autoimmune diseases. 

Added 7 months ago

European S3-Guidelines on the systemic treatment of psoriasis vulgaris

In recognition of the impact of psoriasis on patients the World Health Assembly (WHA) in May 2014 supported including psoriasis into the group of non-communicable diseases.

Added 7 months ago

Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment

Familial hypercholesterolaemia (FH) is a common genetic cause of premature coronary heart disease (CHD). Globally, one baby is born with...

Added 2 years ago

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Journal articles

Genomic classification of cutaneous melanoma.

We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients.

Added 6 days ago

Nonacog beta pegol in previously treated children with hemophilia B: results from an international open-label phase 3 trial.

Background: Nonacog beta pegol is a recombinant glycoPEGylated factor IX with an extended half-life, developed to improve care for patients with hemophilia B.

Added 7 days ago

Pharmacokinetics of a novel extended half-life glycoPEGylated factor IX, nonacog beta pegol (N9-GP) in previously treated patients with haemophilia B: results from two phase 3 clinical trials.

Introduction: Nonacog beta pegol (N9-GP) is a glycoPEGylated recombinant factor IX (FIX) with an extended half-life developed for routine prophylaxis and the prevention and treatment of bleeding episodes ...

Added 7 days ago

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Clinical trials

Setmelanotide for the treatment of early-onset POMC deficiency obesity

The purpose of the study is to determine the effect of setmelanotide (RM-493) on weight and other factors in patients with pro-opiomelanocortin (POMC) deficiency obesity due to rare bi-allelic loss-of function POMC or PCSK1 genetic mutations.

Added 11 months ago

A Safety, Tolerability, and Efficacy Study of Intracerebroventricular BMN 190 in Pediatric Patients < 18 Years of Age With CLN2 Disease

This Phase 2 open-label, multicenter study will evaluate the safety, tolerability, and efficacy of BMN 190 intracerebroventricular (ICV) administration every other week (qow) for a period of 96 weeks, in patients with CLN2.

Added 2 months ago

Antiepileptic Efficacy Study of GWP42003-P in Children and Young Adults With Dravet Syndrome

To investigate the potential antiepileptic effects of cannabidiol (GWP42003-P) in children and young adults with Dravet syndrome.

Added 3 years ago

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Blog Posts

Hugh Harvey

Metrics Madness

Posted 1 year ago

You shouldn't judge a book by its cover. That much is true, but it's also common sense not to judge a book by measuring the whiteness of its pages, or the amount of hamsters you can place on it. So why do we measure the fabulous NHS with nonsense metrics?

Kimberley Kendall

An Introduction to Complex Disease Genetics

Posted 3 years ago

What's the difference between a gene 'for' a disease and genes that predispose you to susceptibility? How can we use markers to determine the likelihood a patient will develop a disease? What's nature and what's nurture?

Dr Kimberley Kendall introduces the complexities of Disease Genetics. Affecting the whole of medicine, disease genetics are already revolutionising how we think about medicine. We welcome your views in the comments.


Association of adherence to lifestyle recommendations and risk of colorectal cancer: a prospective Danish cohort study

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Union of European Medical Specialists (via European Accreditation Council for CME)
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The diagnostic value of hyperammonemia induced by the non-ischemic forearm exercise test

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BMJ Learning - British Medical Learning
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Carcinoma of unknown primary origin: diagnosis and management: putting NICE guidelines into practice

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Union of European Medical Specialists (via European Accreditation Council for CME)
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