Data from multiple sources - Curated by Toby Galbraith - Last updated 06 June 2017

Latest news articles

Added 8 days ago Drug news

Phase III trial of Coagadex (Coagulation Factor X, Human) shows benefits in Hereditary Factor X deficiency- Bio Products Lab

Bio Products Laboratory Limited has presented new data from TEN02, the Phase III, prospective study of Coagadex (Coagulation Factor X,...

Added 9 days ago Drug news

FDA clears the way for Amicus Therapeutics to submit an NDA to the agency for for the oral precision medicine migalastat for Fabry disease in the fourth quarter of 2017.

Amicus Therapeutics plans to submit a new drug application (NDA) to the FDA for the oral precision medicine migalastat for...

Added 12 days ago Drug news

FDA approves Endari (L-glutamine oral powder) in sickle cell disease- Emmaus Life Sciences

Emmaus Life Sciences announced that the FDA approved Endari (L-glutamine oral powder) to reduce the severe complications of sickle cell...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Cystic Fibrosis

View disease awareness information, treatment options and European Cystic Fibrosis Society best practice guidelines

Visit Cystic Fibrosis


Bedwetting

Essential screening, diagnosis and best strategies to manage bedwetting

Visit Bedwetting


Chronic Obstructive Pulmonary Disease (COPD)

View highlights from recent congresses presented in new expert videos with leading physicians

Visit Chronic Obstructive Pulmonary Disease (COPD)


 

Guidelines

Canadian Guidelines for the Management of Plaque Psoriasis 2009

Since the publication of the 2009 Canadian Guidelines for the Management of Plaque Psoriasis, significant advances have been made in determining the role of T cells in inflammatory and autoimmune diseases. 

Added 5 months ago

European S3-Guidelines on the systemic treatment of psoriasis vulgaris

In recognition of the impact of psoriasis on patients the World Health Assembly (WHA) in May 2014 supported including psoriasis into the group of non-communicable diseases.

Added 5 months ago

Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment

Familial hypercholesterolaemia (FH) is a common genetic cause of premature coronary heart disease (CHD). Globally, one baby is born with...

Added 2 years ago

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Journal articles

Cerliponase Alfa: First Global Approval.

Cerliponase alfa (Brineura™) is a recombinant human tripeptidyl peptidase-1 (TPP1) being developed by BioMarin Pharmaceutical Inc. for use in patients with neuronal ceroid lipofuscinosis type 2 (CLN2)...

Added 22 days ago

The clinical landscape for SMA in a new therapeutic era.

Despite significant advances in basic research, the treatment of degenerative diseases of the nervous system remains one of the greatest challenges for translational medicine.

Added 22 days ago

Nusinersen: First Global Approval.

Spinal muscular atrophy (SMA) is a rare autosomal recessive disorder characterized by muscle atrophy and weakness resulting from motor neuron degeneration in the spinal cord and brainstem.

Added 22 days ago

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Clinical trials

Setmelanotide for the treatment of early-onset POMC deficiency obesity

The purpose of the study is to determine the effect of setmelanotide (RM-493) on weight and other factors in patients with pro-opiomelanocortin (POMC) deficiency obesity due to rare bi-allelic loss-of function POMC or PCSK1 genetic mutations.

Added 9 months ago

A Safety, Tolerability, and Efficacy Study of Intracerebroventricular BMN 190 in Pediatric Patients < 18 Years of Age With CLN2 Disease

This Phase 2 open-label, multicenter study will evaluate the safety, tolerability, and efficacy of BMN 190 intracerebroventricular (ICV) administration every other week (qow) for a period of 96 weeks, in patients with CLN2.

Added 22 days ago

Dose Optimization Study of Idelalisib in Follicular Lymphoma

This study will optimize the safety and efficacy of chronic administration of idelalisib in participants with follicular lymphoma (FL) and evaluate the overall safety profile of idelalisib...

Added 1 month ago

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Blog Posts

Hugh Harvey

Metrics Madness

Posted 1 year ago

You shouldn't judge a book by its cover. That much is true, but it's also common sense not to judge a book by measuring the whiteness of its pages, or the amount of hamsters you can place on it. So why do we measure the fabulous NHS with nonsense metrics?

Kimberley Kendall

An Introduction to Complex Disease Genetics

Posted 3 years ago

What's the difference between a gene 'for' a disease and genes that predispose you to susceptibility? How can we use markers to determine the likelihood a patient will develop a disease? What's nature and what's nurture?

Dr Kimberley Kendall introduces the complexities of Disease Genetics. Affecting the whole of medicine, disease genetics are already revolutionising how we think about medicine. We welcome your views in the comments.

CME

Association of adherence to lifestyle recommendations and risk of colorectal cancer: a prospective Danish cohort study

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Union of European Medical Specialists (via European Accreditation Council for CME)
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The diagnostic value of hyperammonemia induced by the non-ischemic forearm exercise test

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BMJ Learning - British Medical Learning
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Carcinoma of unknown primary origin: diagnosis and management: putting NICE guidelines into practice

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Union of European Medical Specialists (via European Accreditation Council for CME)
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