Data from multiple sources - Curated by Toby Galbraith - Last updated 13 April 2017

Latest news articles

Added 18 days ago Drug news

Phase III MISSION programme of two trials of elenbecestat are initiated by Eisai and Biogen for treatment of Alzheimers disease

Eisai Co., Ltd. announced that enrollment has commenced in Japan for MISSION AD1, a global Phase III clinical study of...

Added 19 days ago Drug news

Acorda Therapeutics reports two long term safety studies for CVT-301 for treatment of Parkinson's disease.

Acorda Therapeutics, Inc. announced results from two ongoing, long-term safety studies of CVT-301 in people with Parkinson’s that showed no...

Added 1 month ago Drug news

MitraClip system shows benefits in study of transcatheter mitral valve repair- Abbott

Abbott announced favorable one-year outcomes from the largest study of real-world experience for the MitraClip system in transcatheter mitral valve...

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Learning Zones

An Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Acute and Advanced Heart Failure

What are the most effective treatments for acute heart failure? Can you define advanced heart failure? Discover here...

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Epidemiology, pathophysiology, diagnosis/treatment guidelines, recent publication summaries and more

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Prostate Cancer

How can you balance the harmful effects of treatment with control of prostate cancer growth in otherwise healthy patients?

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American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity.

Development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and the American College of Endocrinology...

Added December 2016 ago

Care of dying adults in the last days of life

This guideline covers the clinical care of adults (18 years and over) who are dying during the last 2 to...

Added December 2015 ago

European Stroke Organisation (ESO) guidelines for the management of temperature in patients with acute ischemic stroke

Hyperthermia is a frequent complication in up to 50% of patients with acute ischemic stroke, and it was shown to...

Added July 2015 ago

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Journal articles

Outcomes of patients with chronic lymphocytic leukemia treated with first-line idelalisib plus rituximab after cessation of treatment for toxicity.

Background: More active therapies are needed for older and unfit patients with chronic lymphocytic leukemia (CLL) who are not eligible for chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab.

Added April 2017 ago

Safinamide: A Review in Parkinson's Disease.

Safinamide (Xadago®) is an orally active, selective, reversible monoamine oxidase-B inhibitor with both dopaminergic and non-dopaminergic (glutamatergic) properties. In the EU, safinamide is approved for the treatment ...

Added April 2017 ago

The safety and efficacy of safinamide mesylate for the treatment of Parkinson's disease.

Safinamide (brand name Xadago®, Zambon S.p.A) is a third-generation reversible MAO-B inhibitor, which also blocks sodium voltage-sensitive channels and modulates stimulated release of glutamate.

Added April 2017 ago

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Clinical trials

Levosimendan Compassionate Use in Pediatric Patients With Advanced Decompensated Heart Failure

Open label study of levosimendan; planned comparison for effectiveness and safety to historic matched case controls from...

Added November 2016 ago

Prove of Concept Study, to Evaluate the Efficacy, Safety, and Tolerability of IBEROGAST in the Treatment of Bowel Troubles in Patients With Parkinson's Disease (PHYTOPARK)

The main objective of this study is to evaluate the efficacy of STW5 Iberogast, over a 28-day period, for the...

Added April 2016 ago

Comparing Regional Anaesthesia to Systemic Analgesia to Decrease Post-Operative Delirium in Acute Hip Fracture Surgery (RASAPOD)

Post-operative delirium is common after hip fracture surgery and is associated with increased length of hospital stay, delayed recovery and...

Added March 2016 ago

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Blog Posts

Hugh Harvey

Metrics Madness

Posted 1 year ago

You shouldn't judge a book by its cover. That much is true, but it's also common sense not to judge a book by measuring the whiteness of its pages, or the amount of hamsters you can place on it. So why do we measure the fabulous NHS with nonsense metrics?

Vincent de Luise

The End of Sight at the End of Life

Posted 1 year ago

I presented this talk, "The End of Sight at the End of Life," on  4/4/2013 at a Harvard University  "Think Tank" on Health and Aging. The two-day conference, held at the Charles Hotel in Cambridge, Massachusetts, brought together prominent scholars from the Harvard School of Public Health as well as global experts in economics, health care policy and longevity, for a fascinating and thought-provoking colloquium on the demographics and consequences of aging in all societies.

Bob Bury

Legalised killing – leave doctors out of it.

Posted 2 years ago

Would you trust a doctor to decide if you are an appropriate subject for assisted dying? I wouldn't, neither should you, and my colleagues who are not fortunate enough to be retired will be crazy if they allow themselves to be dragged into the process. Proponents of legislative change should man up and face the implications of their proposals, without hiding behind the medical profession.


Heart failure: clinical review

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COPD: clinical review

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Older lady with uncontrolled COPD

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