Latest news articles

Added 14 hours ago Drug news

Janssen responds to the national institute for health and care excellence (nice) draft guidance for STELARA® (ustekinumab) in ulcerative colitis

Janssen responds to NICE’s preliminary decision not to recommend STELARA® (ustekinumab) within its marketing authorisation, for treating moderately to severely active ulcerative colitis (UC).

Added 1 day ago Congress news

ECCO 2020: A preview of the scientific programme

We’ve taken a look at some of the most compelling abstracts, posters and plenaries from the ECCO 2020 programme - take a look at our review.

Added 2 days ago Drug news

IDMC recommends early halt of phase III SANET-p study of HMPL 012 in neuroendocrine tumors – pancreatic.- Hutchison China MediTech

Hutchison China MediTech Limited announced that the independent Data Monitoring Committee of the Phase III pivotal study of HMPL 012...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Inflammatory Bowel Disease Knowledge Centre

Inflammatory Bowel Disease Knowledge Centre

The Inflammatory Bowel Disease (IBD) Knowledge Centre contains key information relating to the epidemiology and pathophysiology of Crohn’s disease and ulcerative colitis, highlighting prevalence, impact and unmet needs and the underlying inflammatory processes that drive IBD, considering some of the key inflammatory pathways.

Inflammatory bowel disease assessment tools

Inflammatory bowel disease assessment tools

'New IBD assessment tools at a glance' - an educational symposium sponsored by Sandoz.

Fluid Management

Fluid Management

Are you up-to-date with the latest evidence of effective procedures for fluid management?

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Guidelines

Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management

This guideline update covers adults (18 years and older) with symptoms of dyspepsia, symptoms suggestive of GORD, or both. It...

Added 5 years ago

Gastro-oesophageal reflux disease in children and young people: diagnosis and management

This guideline covers diagnosing and managing gastro-oesophageal reflux disease in children and young people (under 18s).

Added 5 years ago

Ulcerative colitis: management

This guideline covers the management of ulcerative colitis in children, young people and adults. It aims to help professionals to provide consistent high-quality care and it highlights the importance of advice and support...

Added 5 months ago

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Journal articles

The PROSIT-BIO Cohort: A Prospective Observational Study of Patients with Inflammatory Bowel Disease Treated with Infliximab Biosimilar.

Background: Few data are available on the safety and efficacy of infliximab biosimilar CT-P13 in patients with ulcerative colitis and Crohn's disease.

Added 2 days ago

Switching to biosimilars: current perspectives in immune-mediated inflammatory diseases.

Area covered: We discuss the current considerations related to switching from reference products to biosimilars from a physician and patient perspective. We review the clinical data and real-life experience on switching patients...

Added 2 days ago

Switching Reference Medicines to Biosimilars: A Systematic Literature Review of Clinical Outcomes.

Introduction: To evaluate the possibility that switching from reference biologic medicines to biosimilars could lead to altered clinical outcomes, including enhanced immunogenicity, compromised safety, or diminished efficacy...

Added 2 days ago

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Clinical trials

Evaluate the Efficacy and Safety of HLX10 in Chronic Hepatitis B Patients

A multiple-center, open-label, Phase II clinical trial to evaluate the safety and the efficacy of HLX10 in chronic hepatitis B patients.

Added 2 months ago

Evaluating the Safety and Efficacy of Inarigivir in Non-cirrhotic Treatment Naive Subjects Infected With Hepatitis B Virus

An open-label, Phase 2, exploratory study to examine the safety and efficacy of inarigivir in non-cirrhotic, hepatitis B treatment-naive subjects with chronic HBV infection.

Added 2 months ago

A Phase 3/4 Clinical Study to Evaluate the Efficacy and Safety of Aramchol Versus Placebo in Subjects With NASH (ARMOR) (ARMOR)

The primary objectives of the study are to evaluate the effect of Aramchol as compared to placebo on NASH resolution, fibrosis improvement and clinical outcomes related to progression of liver disease.

Added 2 months ago

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Blog Posts

Allen Wellings

UEGW 2018 | Day 5 Highlights

Posted 1 year ago

A number of presentations and abstracts shared updates on the latest developments for new treatments and therapies, some of which are pioneering new modes of action. Here we look to the horizon, gaining insights into the latest data for novel treatments targeting Janus kinase (JAK) signalling, MAdCAM-1-mediated adhesion and the interleukin IL-23.
 

 

Georgina Mason

UEGW 2018 | Day 4 Highlights

Posted 1 year ago

While clinical trials have demonstrated the efficacy of new biologics used in ulcerative colitis and/or Crohn’s disease, it is apparent that patients enrolled into clinical trials are not representative of the general patient population. Real-world evidence offers the chance to fill this gap and provide insights into how these treatments perform in everyday clinical practice. In today’s article we review some of the real-world data shared at UEG Week on vedolizumab and ustekinumab, as well as comparison of the originator and biosimilar versions of infliximab.

Georgina Mason

UEGW 2018 | Day 3 Highlights

Posted 1 year ago

The introduction of biologic therapies in the last 20 years has revolutionised the management of IBD. However, questions remain over the best approach to its management, such as when to introduce, switch and de-escalate biologics. Several posters and presentations addressed these topics at UEG Week 2018; here is a selection of some of the highlights.

CME

Association of adherence to lifestyle recommendations and risk of colorectal cancer: a prospective Danish cohort study

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Union of European Medical Specialists (via European Accreditation Council for CME)
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A case of bleeding oesophageal varices

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Union of European Medical Specialists (via European Accreditation Council for CME)
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Idiopathic constipation and nocturnal enuresis in childhood: a guide to management: putting NICE guidelines into practice

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BMJ Learning - British Medical Learning
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