Latest news articles

Added 3 days ago Drug news

FDA Allergenic Products Advisory Committee votes to support the use of Palforzia (AR101) for peanut allergy.- Aimmune Therapeutics Inc.

Aimmune Therapeutics, Inc. announced that the Allergenic Products Advisory Committee (APAC) convened by the FDA voted to support the use...

Added 15 days ago Drug news

Entresto improved measures of heart structure and function in HFrEF patients in new Novartis study; additional data complement findings.

Novartis announced results from two new clinical trials evaluating improvement in heart structure and function and long-term safety of Entresto...

Added 16 days ago Drug news

AstraZeneca announced detailed results from the phase III DAPA-HF trial that showed Farxiga plus standard of care reduced both the incidence of cardiovascular death and the worsening of heart failure.

AstraZeneca announced detailed results from the landmark Phase III DAPA-HF trial that showed Farxiga (dapagliflozin) on top of standard of...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

ESICM LIVES Highlights

ESICM LIVES Highlights

ESICM LIVES Congress 2018: Bringing you the latest news and insights from the 31st ESICM LIVES Congress, 20–24 October 2018 Paris, France.

Fibrinogen Deficiency in Bleeding

Fibrinogen Deficiency in Bleeding

Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.

Chronic Lymphocytic Leukaemia (CLL)

Chronic Lymphocytic Leukaemia (CLL)

Refine your knowledge of chronic lymphocytic leukaemia (CLL) with information on pathophysiology, diagnosis, treatment options and more

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Guidelines

Preterm labour and birth

This guideline covers the care of women at increased risk of or with symptoms and signs of preterm labour (before 37 weeks) and women having a planned preterm birth.

Added 3 years ago

Suspected neurological conditions: recognition and referral

This guideline covers the initial assessment of symptoms and signs that might indicate a neurological condition. It helps non-specialist healthcare professionals to identify people who should be offered referral for specialist investigation.

Added 1 month ago

Stroke and transient ischaemic attack in over 16s: diagnosis and initial management

This guideline covers interventions in the acute stage of a stroke or transient ischaemic attack (TIA). It offers the best clinical advice on the diagnosis and acute management of stroke and TIA in the 48 hours after onset of symptoms.

Added 1 month ago

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Journal articles

Reversal of oral anticoagulation in patients with acute intracerebral hemorrhage.

In light of an aging population with increased cardiovascular comorbidity, the use of oral anticoagulation (OAC) is steadily expanding. A variety of pharmacological alternatives to vitamin K antagonists (VKA) have emerged...

Added 13 days ago

Reversal agents for direct oral anticoagulants: considerations for hospital physicians and intensivists.

Direct oral anticoagulants (DOACs) include dabigatran etexilate, a direct thrombin inhibitor, and specific inhibitors of activated coagulation factor X (FXa; e.g. apixaban, betrixaban, edoxaban, rivaroxaban).

Added 13 days ago

Andexanet alfa for the reversal of factor Xa inhibitors.

Introduction: Andexanet alfa is a recombinant modified factor Xa protein that has been developed to reverse factor Xa inhibitors. Since May 2018, the FDA has approved its utilization in patients treated with apixaban and...

Added 13 days ago

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Clinical trials

Trial of Andexanet in ICH Patients Receiving an Oral FXa Inhibitor

Randomized, controlled clinical trial evaluating the efficacy and safety of andexanet versus usual standard of care in patients with intracranial hemorrhage anticoagulated with a direct oral anticoagulant

Added 3 months ago

Fibrinogen Concentrate in Isolated Traumatic Brain Injury

The purpose of this study is to try early injection of fibrinogen concentrate in severe isolated traumatic brain injury and investigation the effect of it on post bleeding and complications.

Added 4 months ago

This Study Looks at the Effects of Idarucizumab in Patients Who Take Dabigatran and Need Emergency Surgery or Are Bleeding

The primary objective is to demonstrate reversal of the anticoagulant effect of dabigatran in patients treated with dabigatran etexilate who have uncontrolled or life-threatening bleeding requiring urgent intervention, and in patients treated...

Added 3 months ago

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Blog Posts

Alex Keen

ISICEM 2018 – The Sepsis Six and BUFALO

Posted 1 year ago

At nearly 30 million annual cases and 6 million deaths globally, sepsis is one of the world’s biggest killers. The Sepsis Six and BUFALO aim to speed up the time from sepsis diagnosis to effective treatment by using 6 simple steps, with the aim to improve outcomes across the globe. 

Laura Quittenden

What is AF or Atrial Fibrillation?

Posted 1 year ago

This week, from the 20th to the 26th November it is Global AF Awareness Week. Here we explore Atrial Fibrillation (also called AF or AFib), the most common heart rhythm disorder that can lead to stroke, blood clots, heart failure and other heart-related complications. Over 1 million people have been diagnosed with AF in the UK alone.  

Hugh Harvey

Metrics Madness

Posted 3 years ago

You shouldn't judge a book by its cover. That much is true, but it's also common sense not to judge a book by measuring the whiteness of its pages, or the amount of hamsters you can place on it. So why do we measure the fabulous NHS with nonsense metrics?

CME

Dermatological emergencies in children

Accrediting body
MIMS Learning - Monthly Index of Medical Specialities
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Emergencies in dermatology

Accrediting body
MIMS Learning - Monthly Index of Medical Specialities
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Breaking bad news: a how to do it guide

Accrediting body
Union of European Medical Specialists (via European Accreditation Council for CME)
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90
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