Data from Pharmawand - Curated by EPG Health - Date added 11 February 2019

Oral delivery is the simplest and least invasive way to deliver many pharmaceuticals, but many drugs and medications, including insulin, cannot survive passage through the stomach or the gastrointestinal tract. Abramson et al. developed an ingestible delivery vehicle that could self-reorient from any starting position so as to attach to the gastric wall. Encapsulation of a spring in a sugar casing allowed for triggered actuation for the delivery of biomolecules. The approach successfully provided active insulin delivery in pigs.

See-" An ingestible self-orienting system for oral delivery of macromolecules"- Alex Abramson, Ester Caffare-Salvador, Minsoo Khang, David Dellal, David Silverstein, Yuan Gao, Morten Revsgaard Frederiksen, et al.,-Science 08 Feb 2019: Vol. 363, Issue 6427, pp. 611-615 DOI: 10.1126/science.aau2277.

Comment: Insulin injections are the common mode of delivery for people with diabetes. An alternative is Alfrezza which works by nasal delivery but it has not been so popular.Researchers from MIT and Novo Nordisk have now developed a pill that can be swallowed and that attaches itself to the wall of the stomach and releases insulin to the blood vasculature.


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