Data from Pharmawand - Curated by EPG Health - Date added 14 March 2018

Biotronik announced that patient enrollment for the BIOSTEMI study has been completed. STEMI is a potentially fatal type of heart attack, caused by prolonged obstruction of blood supply in the heart. More than 730,000 cardiac artery disease (CAD) patients globally lost their lives to STEMI heart attacks in 2016.

BIOSTEMI, a randomized, controlled superiority study, is the first trial intended to confirm the superiority of the Orsiro2 hybrid drug-eluting stent (DES) to the Xience Xpedition3 (EES) in patients with ST-Elevation Myocardial Infarction (STEMI), after a statistically significant difference was seen in the STEMI subgroup of the BIOSCIENCE trial in a smaller cohort (n=407). Indeed, results from the STEMI subgroup show that the target lesion failure rate at 24 months was 5.4% vs. 10.8% in Orsiro and Xience respectively. The difference was significant: p=0.043. The investigator-initiated, international multi-center BIOSTEMI trial has currently enrolled 1,250 patients in 16 study centers across Switzerland and Italy. STEMI patients were randomized to receive treatment with either Orsiro or Xience Xpedition.

BIOSTEMI’s primary endpoint is Target Lesion Failure (TLF) at 12 months, defined as a composite of cardiac death, target vessel myocardial infarction and clinically-driven target lesion revascularization. Follow up is planned at five years. More details of the trial design were published in EuroIntervention at the beginning of December 2017.


You will need to login, to leave a comment. is not monitored for collection of adverse event reports. Any adverse events should be reported to your national reporting agency and/or the manufacturer.

Learning Zones

An Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Acute and Advanced Heart Failure

Acute and Advanced Heart Failure

What are the most effective treatments for acute heart failure? Can you define advanced heart failure? Discover here...

+ 3 more

Cardiovascular Metabolism Knowledge Centre

Cardiovascular Metabolism Knowledge Centre

The Cardiovascular Metabolism Knowledge Centre is an information hub providing expert insight into the management of hypertension and type 2 diabetes. This Knowledge Centre contains a wealth of scientific video content offering insights and opinion from some of the leading experts in the field.

Migraine Knowledge Centre

Migraine Knowledge Centre

The Migraine Knowledge Centre features latest research on the prevalence and impact of migraine, the proposed neurological basis of the condition (and how this is being translated into new and exciting drug therapies), as well as current patient care strategies collated from headache organisations worldwide.

Load more

Related Content