This site is intended for healthcare professionals
Journals
  • Home
  • /
  • Journals
  • /
  • Hepatitis
  • /
  • Microbiota and nonalcoholic fatty liver disease/no...
Journal

Microbiota and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH).

Read time: 1 mins
Published:1st May 2019
Author: Duarte SMB, Stefano JT, Oliveira CP.
Availability: Free full text
Ref.:Ann Hepatol. 2019;18(3):416-421.
DOI:10.1016/j.aohep.2019.04.006
Microbiota and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH)


Genetic predisposition, the intestinal microbiota (IM) and environmental factors, such as sedentary lifestyle and inadequate diet, should be considered as critical factors for the development of nonalcoholic fatty liver disease (NAFLD). Recently, some studies have demonstrated an association between dysbiosis and NAFLD; however, the exact mechanisms that lead to intestinal membrane damage, bacterial translocation and inflammation are not well elucidated. Due to the relevance of this theme, the IM and its metabolites have received special attention in recent years in an attempt to better understand the mechanisms related to the prevention, physiopathology, and treatment of NAFLD. In this paper, we provide a review of the human IM and its role in diet, obesity, and the development/progression of NAFLD/NASH, as well as the use of prebiotics and probiotics in the modulation of IM.

 

Read abstract on library site

Access full article