Horizons

Opinion & insight from our Clinical Steering Group

Horizons, led by a team of experts from our Clinical Steering Group, is a series of scientific articles which take a deep dive into the emerging trends in the healthcare landscape, kickstarting a dialogue about how treatments and strategies should be best implemented for the benefit of patients.

We're discussing new treatments, especially in oncology, and how they are set to disrupt healthcare practices in the coming years. Some of the topics we'll be tackling include:

  • Antibody-drug conjugates

  • Immuno-oncology

  • Oral proteasome inhibitors – multiple myeloma

  • CDK 4&6

  • Biosimilars – both as a class and specifics

  • PARP inhibitors

  • CAR-T

What's on the horizon?

Marshall Pearce

Cancer immunotherapies

Posted 1 month ago

It was the winner of the 1908 Nobel prize for medicine, Paul Ehrlich, who is first credited with discussing the concept of a “magic bullet”, able to target specific cells without damaging healthy tissue. With the advent of immunotherapy, as well as antibody-drug conjugates, we are beginning to realise this vision.

Marshall Pearce

Antibody-drug conjugates (ADCs)

Posted 1 month ago

Over the past couple of decades, there have been advances in a class of drugs which for a long time was purely theoretical: antibody-drug conjugates (ADCs). The concept underlying ADCs is elegant – what if it were possible to ‘target’ particular groups of cells with a cytotoxic agent, rather than exposing every cell of the body to it?

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