ADVERSE REACTIONS The following side effects, some of them serious, have been associated with the use of TRIDIONE (trimethadione). Gastrointestinal Nausea, vomiting, abdominal pain, gastric distress. CNS/Neurologic Drowsiness, fatigue, malaise, insomnia, vertigo, headache, paresthesias, precipitation of grand mal seizures, increased irritability, personality changes. Drowsiness usually subsides with continued therapy. If it persists, a reduction in dosage is indicated. Hematologic Bleeding gums, epistaxis, retinal and petechial hemorrhages, vaginal bleeding, neutropenia, leukopenia, eosinophilia, thrombocytopenia, pancytopenia, agranulocytosis, hypoplastic anemia, and fatal aplastic anemia. Dermatologic Acneiform or morbilliform skin rash that may progress to exfoliative dermatitis or to severe forms of erythema multiforme. Other Hiccups, anorexia, weight loss, hair loss, changes in blood pressure, albuminuria, hemeralopia, photophobia, diplopia. Fatal nephrosis has occurred. Hepatitis has been reported rarely. Lupus erythematosus, and lymphadenopathies simulating malignant lymphoma, have been reported. Pruritus associated with lymphadenopathy and hepatosplenomegaly has occurred in hypersensitive individuals. A myasthenia gravis-like syndrome has been reported.