Data from FDA - Curated by EPG Health - Last updated 27 July 2017


INDICATIONS AN USAGE: 1. For therapeutic use in patients with hypokalemia with or without metabolic alkalosis; in digitalis intoxication and in patients with hypokalemic familial periodic paralysis. 2. For prevention of potassium depletion when the dietary intake of potassium is inadequate in the following conditions; patients receiving digitalis and diuretics for congestive heart failure; hepatic cirrhosis with ascites; states of aldosterone excess with normal renal function; potassium-losing nephropathy, and certain diarrheal states. 3. The use of potassium salts in patients receiving diuretics for uncomplicated essential hypertension is often unnecessary when such patients have a normal dietary pattern. Serum potassium should be checked periodically, however, and, if hypokalemia occurs, dietary supplementation with potassium-containing foods may be adequate to control milder cases. In more severe cases supplementation with potassium salts may be indicated.

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Advisory information

CONTRAINDICATIONS: Potassium supplements are contraindicated for patients having hyperkalemia, since a further increase in serum potassium level in these patients can results in cardiac arrest. Hyperkalemia may complicate any of the following conditions;chronic renal failure; systemic acidosis, such as diabetic acidosis, acute dehydration; extensive tissue breakdown, as in severe burns; adrenal insufficiency. Hypokalemia should not be treated by the simultaneous use of potassium salts and a potassium sparing diuretic, such as spironolactone or triamterene, since the concomitant use of these medications can result in severe hyperkalmia.
Special warnings and precautions
PRECAUTIONS: General Precautions - The diagnosis of potassium depletion is ordinarily made by demonstrating hypokalemia in a patient with a clinical history suggesting a cause for potassium depletion. When interpreting the serum potassium concentration, the physician should be aware that acute alkalosis can cause hypokalemia without showing a deficit in total body potassium. Acute acidosis can increase the serum potassium level to normal even with a reduced total body potassium.. Thus close attention to acid-base balance, serum electrolytes, the clinical status of the patient, and the ECG is required in the treatment of potassium depletion.
Adverse reactions
ADVERSE REACTIONS: Abdominal discomfort, diarrhea, vomiting, and nausea are the most common adverse reactions tooral potassium supplements. These adverse reactions occur most frequently when the preparation is not taken with food, is not properly diluted, or not completely dissolved. Hyperkalemia occurs infrequently in patients with normal renal function who receive oral potassium supplements. The following are symptoms of hyperkalemia: mental confusion, unexplained anxiety, cardiac arrhythmias, numbness or tingling in lips, feet, or hands, difficult breathing or shortness of breath, weakness or heaviness of legs, and unusual fatigue or weakness. (See Contraindications, Warnings, and Overdosage).

Usage information

Dosing and administration
DOSAGE AND ADMINISTRATION: Adults - One effervescent tablet (25 mEq potassium) completely dissolved in three to four ounces or more of cold water and taken two to four times daily, or as directed by physician. It is suggested this potassium solution be taken with meals and sipped slowly over a five to ten minute period. Do not open foil pouch until time of use.
Pregnancy and lactation
Nursing Mothers - Because many drugs are excreted in human milk, there exists the potential for serious adverse reactions in nursing infants from oral potassium supplements. Therefore, it should be decided whether to discontinue nursing or to discontinue the drug, considering the importance of the drug to the mother.


Drug Interactions - Severe hyperkalemia can be produced by the simultaneous administration of potassium supplements and a potassium-sparing diuretic (see Contraindications). Potassium supplements should be used carefully by patients who are using salt substitutes, because many of these substitutes contain large amounts of potassium. This simultaneous use could produce hyperkalemia.

More information

Category Value
Agency product number HM5Z15LEBN
Orphan designation No
Product NDC 50201-2400
Date Last Revised 14-12-2010
RXCUI 1088772
Marketing authorisation holder Tower Laboratories Ltd