For the treatment of non - insulin dependent diabetes in patients who respond inadequately to dietary treatment. It should not be used to replace dietetic therapy in the obese diabetic patient.
Typhoid fever and life-threatening infections, particularly those caused by Haemophilus influenzae where other antibiotics will not suffice.
Aprepitant and fosaprepitant, commonly used for the prevention of chemotherapy-induced nausea and vomiting, alter cytochrome P450 activity.