Data from FDA - Curated by EPG Health - Last updated 19 December 2016
PRECAUTIONS General: Thyroid hormones reduce the TSH response to TRH.
Accordingly, patients in whom TRH is to be used diagnostically should be taken off liothyronine (T3) approximately seven days prior to testing and should be taken off thyroid medications containing levothyroxine (T4), e.g., desiccated thyroid, thyroglobulin, or liotrix, at least 14 days before testing.
Hormone therapy is NOT to be
It is not advisable to withdraw maintenance doses of adrenocortical drugs used in the therapy of known hypopituitarism.
Several published reports have shown that
Therapeutic doses of acetylsalicylic acid (2 to 3.6 g/day) have been reported to
The ingestion of acetylsalicylic acid caused the peak level of TSH to
In both cases, the TSH peak occurred 30
Generally, the side effects are moor, have
Cardiovascular reactions: Marked changes in
Endocrine reaction: Breast enlargement and
Rarely, convulsions may occur in patients with predisposing conditions, e.g., epilepsy,
Less frequently reported were:
Pituitary apoplexy requiring
DOSAGE AND ADMINISTRATION TRH is intended for intravenous administration with the patient in the supine position.
The drug is administered as a bolus over a period of 15 to 30 seconds, with the patient remaining supine until all scheduled post injection
Blood pressure should be measured before TRH is administered and at frequent intervals during the first
Have the patient urinate before injecting TRH. Adults: 500?
Doses between 200 and 500?g have been used.
500?g is considered the
Children age 6 to 16 years: 7?g/ kg body weight up to a dose of 500?
Infants and children up to 6 years:
Elevated serum lipids may interfere with the TSH assay.
Thus, fasting (except in patients with hypopituitarism) or
|Date Last Revised||19-06-2012|
|Type||HUMAN PRESCRIPTION DRUG|
|Marketing authorisation holder||AnazaoHealth Corporation|