Data from FDA (Food and Drug Administration, USA) - Curated by EPG Health - Last updated 08 February 2017
The dose of theophylline selected for
Monitoring Serum Theophylline
Specifically, the serum theophylline concentration should be measured as follows:
When initiating therapy to guide final dosage
Whenever signs or symptoms of theophylline toxicity are present.
Whenever there is a new illness,
For most patients, steady-state will be reached after 3 days of dosing when
A trough concentration (i.e., at the end of the dosing interval) provides
If the serum sample is drawn more than seven hours after the dose, the results must be interpreted with
In contrast, when signs or symptoms of theophylline toxicity are present, the serum sample should be obtained as soon as possible, analyzed immediately, and
In patients in whom decreased serum protein binding is suspected (e.g., cirrhosis, women during the third trimester of pregnancy), the concentration of
Effects on Laboratory Tests As a result of its pharmacological effects, theophylline at serum concentrations within the 10 to
Theophylline at serum concentrations within the 10 to 20 mcg/mL range may also transiently
The transient caffeine-like
During the initiation of theophylline therapy, caffeine-like
Initiation of theophylline therapy at a
Dosage reduction may alleviate the caffeine-like
In patients with hypoxia secondary to COPD, multifocal atrial tachycardia and
There have been a few isolated reports of seizures at serum theophylline concentrations <20 mcg/mL in patients with an underlying neurological disease or in elderly patients.
The occurrence of seizures in elderly patients with serum theophylline concentrations <20 mcg/mL may be secondary to decreased protein binding resulting in a
Manifestations of theophylline toxicity.
NURSING MOTHERS Theophylline is excreted into breast milk and may cause irritability or other signs of
The concentration of theophylline in breast milk is about equivalent to the maternal serum concentration.
An infant ingesting a liter of breast milk containing 10 to 20 mcg/mL of theophylline a day is likely to receive 10 to 20 mg of theophylline per day.
|Date Last Revised||07-07-2011|
|Type||HUMAN PRESCRIPTION DRUG|
|Marketing authorisation holder||REMEDYREPACK INC.|