PRECAUTIONS General - Nonsusceptible organisms, including fungi, may proliferate with the use of this preparation. Hypersensitivity reactions may recur when a sulfonamide is readministered, irrespective of the route of administration, and cross hypersensitivity between different sulfonamides may occur. If SEB-Prev™ Wash produces signs of hypersensitivity or other untoward reactions, discontinue use of the preparation. Systemic absorption of topical sulfonamides is greater following application to large, infected, abraded, denuded, or severely burned areas. Under these circumstances, potentially any of the adverse effects produced by the systemic administration of these agents could occur and appropriate observations and laboratory determinations should be performed. Information For Patients - Patients should discontinue SEB-Prev™ Wash if the condition becomes worse, or if a rash develops in the area being treated or elsewhere. SEB-Prev™ Wash also should be discontinued promptly and the physician notified if any arthritis, fever, or sores in the mouth develop. For external use only. Avoid contact with eyes and mucous membranes. Keep this and all medications out of reach of children. In case of accidental ingestion, call a physician or poison control center immediately (see OVERDOSAGE). Drug Interactions - SEB-Prev™ Wash is incompatible with silver preparations. Carcinogenesis, Mutagenesis, Impairment of Fertility - Long-term animal studies for carcinogenic potential have not been performed on SEB-Prev™ Wash to date. Studies on reproduction and fertility also have not been performed. One author detected chromosomal nondisjunction in the yeast, Saccharomyces cerevisiae, following application of sulfacetamide sodium. The significance of this finding to the topical use of sulfacetamide sodium in the human is unknown. Pregnancy: Teratogenic effects: Pregnancy Category C - Animal reproduction studies have not been conducted with SEB-Prev™ Wash. It also is not known whether SEB-Prev™ Wash can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. SEB-Prev™ Wash should be given to a pregnant woman only if clearly needed. Nursing Mothers - It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when SEB-Prev™ Wash is administered to a nursing woman. Pediatric Use - Safety and effectiveness in children under the age of 12 years have not been established.