Lariam 250 mg tablets / Mefloquine 250 mg tablets
Therapy and chemoprophylaxis of malaria. Therapy : Mefloquine is especially indicated for therapy of P. falciparum malaria in which the pathogen has become resistant to other antimalarial agents. Following treatment of P. vivax malaria with mefloquine, relapse prophylaxis with an 8-amino-quinoline derivative, for example primaquine, should be considered in order to eliminate parasites in the hepatic phase. Chemoprophylaxis : Malaria chemoprophylaxis with mefloquine is particularly recommended for travellers to malarious areas in which multiply resistant P. falciparum strains occur. Official guidelines and local information on the prevalence of resistance to antimalarial drugs should be taken into consideration. Official guidelines will normally include WHO and public health authorities. For current advice on geographical resistance patterns and appropriate chemoprophylaxis, current guidelines or the National Travel Health Network and Centre (NaTHNaC) should be consulted, which can be found at http://travelhealthpro.org.uk/diseases/malaria.