Data from FDA - Curated by EPG Health - Last updated 01 June 2018

Indication(s)

INDICATIONS According to the FDA reference text “Clarkes’ Materia Medica 1900”; Crotalus venom preparations are indicated as homeopathic medications for numerous conditions but especially; Cancers. Tongue, inflammation of ; cancer of. Clinical experience shows that Crotoxin also provide relief from some forms of pain. Cobra venom preparations are indicated as homeopathic medications for several conditions but especially for; angina faucium, angina pectoris, asthma, dysmenia (painful menses), grief (depression), headache (migraine), pain in ovaries (ovarian cysts), spinal irritation (back pain) and sore throat. Cardiotoxin is the principal active analgesic component.

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Advisory information

contraindications
CONTRAINDICATIONS CTC-310 is intended to be used as a monotherapy. Clinical experience suggests that concurrent use of radio- or chemotherapy may inhibit the activity of the drug. As the known receptors include those sensitive to nicotine is it is likely that nicotine will inhibit the activity of Crotoxin.
Special warnings and precautions
PRECAUTIONS Pregnancy: No significant data has been collected on the use of Crotoxin during pregnancy. No animal reproduction studies have been conducted to assess the effects of Crotoxin on the developing fetus. Nursing mothers: It is not known whether this drug is distributed into breast milk. Crotoxin is not orally bioavailable therefore it is unlikely to have any detrimental effects Pediatric use: There is no information on the use of Crotoxin in children and young adults.
Adverse reactions
ADVERSE REACTIONS The majority of reported adverse effects associated with CTC-310 result from Crotoxin’s neurotoxic effects. In clinical studies with CTC-310, subjects reported the following dose related adverse effects; anxiety, increased blood pressure, diplopia, nystagmus and strabismus.

Usage information

Dosing and administration
DOSAGE AND ADMINISTRATION The maximum reported tolerable dose of CTC-310 by intramuscular bolus injection is 0.017 mg/Kg. Injection site reactions are common though will subside in 2-3 weeks with continued use. With dose escalation procedures doses of 0.023 mg/Kg have been attained. Subcutaneous administration may be easier and more comfortable that intramuscular without any likely loss in activity.
Pregnancy and lactation
Nursing mothers: It is not known whether this drug is distributed into breast milk. Crotoxin is not orally bioavailable therefore it is unlikely to have any detrimental effects

Interactions

INTERACTIONS No detailed reports of drug interactions have been reported.

More information

Category Value
Agency product number 0QBH3Y8M6J
Orphan designation No
Product NDC 48142-200
Date Last Revised 28-03-2018
Type HUMAN PRESCRIPTION DRUG
Storage and handling STORAGE CTC-310 should be stored refrigerated (2-10°C / 38-50 °F).
Marketing authorisation holder Celtic Biotech Iowa, Inc.