Dosage and Administration Cetacaine Spray should be applied for approximately one second or less for normal anesthesia. Only a limited quantity of Cetacaine is required for anesthesia. Spray in excess of two seconds is contraindicated. Average expulsion rate of residue from spray, at normal temperatures, is 200 mg per second. To apply, insert the Jetco cannula (J-4) firmly onto the protruding plastic stem on the bottle and press the cannula forward to actuate the spray valve. The cannula may be removed and reinserted as many times as required for cleaning, or sterilization, and is autoclavable. Cetacaine Liquid Apply 200 mg (approximately 6 – 7 drops or 0.2 cc) with a cotton applicator or directly to tissue. Do not hold the cotton applicator in position for extended periods of time, since local reactions to benzoate topical anesthetics are related to the length of time of application. Liquid in excess of 400 mg (approx. 12 – 14 drops or 0.4 cc) is contraindicated. *See Cetacaine Liquid Kit instructions for additional directions for application by Luer-lock syringe and applicator tip. Cetacaine Gel Apply 200 mg of gel (a bead approximately 0.5 inch (13 mm) in length and 3/16 inch (5 mm) in diameter) and spread thinly and evenly over the application area. Gel in excess of 400 mg (a bead approximately 1 inch (26 mm) in length and 3/16 inch (5 mm) in diameter) is contraindicated. An appropriate pediatric dosage has not been established for Cetacaine Spray, Liquid or Gel. Dosages should be reduced in the debilitated elderly, acutely ill, and very young patients. Tissue need not be dried prior to application of Cetacaine. Cetacaine should be applied directly to the site where pain control is required. Anesthesia is produced within 30 seconds with an approximate duration of 30 – 60 minutes. Each 200 mg dose of Cetacaine (Spray residue, Liquid or Gel) contains 28 mg of benzocaine, 4 mg of butamben and 4 mg of tetracaine HCl.