Compound Sodium Lactate solution is used in the following indications: - Restoration of extracellular fluid and electrolytes balances or replacement of extracellular fluid loss where isotonic concentrations of electrolytes are sufficient - Short term volume replacement (alone or in association with colloid) in case of hypovolaemia or hypotension. - Regulation or maintenance of metabolic acidosis balance and/or treatment of mild to moderate metabolic acidosis (except lactic acidosis)
Disodium folinate is indicated • to diminish the toxicity and counteract the action of folic acid antagonists such as methotrexate in cytotoxic therapy and overdose in adults and children. In cytotoxic therapy, the procedure is commonly known as “Folinate Rescue”; • in combination with 5-fluorouracil in cytotoxic therapy. Note: Persistently high serum methotrexate levels may also be expected in low-dose methotrexate therapy particularly in pleural effusions, ascites, renal insufficiency and inadequate fluid intake during methotrexate therapy.
Disodium levofolinate is indicated • to diminish the toxicity and counteract the action of folic acid antagonists such as methotrexate in cytotoxic therapy and overdose in adults and children, • in combination with 5-fluorouracil in cytotoxic therapy.
The treatment of tumour-induced hypercalcaemia. The prevention of skeletal related events (pathological fractures, spinal compression, radiation or surgery to bone, hypercalcaemia and bone pain) in patients with breast cancer with bone metastases, or multiple myeloma with bone lesions, in addition to specific treatment of the tumour. Paget's disease of bone.