Latest news articles

Added 5 months ago Drug news

EMA approves Giapreza for hypotension in adults with septic shock.- La Jolla Pharmaceutical

The EMA has approved Giapreza (angiotensin II), from La Jolla Pharmaceutical, for the treatment of patients with refractory hypotension in...

Added 7 months ago Drug news

CHMP recommends approval of Giapreza for refractory hypotension

The Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending the granting of a marketing authorisation...

Added 1 year ago Drug news

FDA approves expanding indication of the Elecsys BRAHMS PCT assay to aid antibiotic treatment in infection.- Roche.

Roche announced that it has received clearance from the FDA for the expanded use of its Elecsys BRAHMS PCT assay...

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Learning Zones

An Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Fibrinogen Deficiency in Bleeding

Fibrinogen Deficiency in Bleeding

Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.

Fluid Management

Fluid Management

Are you up-to-date with the latest evidence of effective procedures for fluid management?

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Consensus on circulatory shock and hemodynamic monitoring

Circulatory shock is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate.

Added 5 years ago

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

The recommendations in this document are intended to provide guidance for the clinician caring for a patient with severe sepsis or septic shock.

Added 7 years ago

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Journal articles

The effect of fibrinogen concentrate administration on coagulation abnormalities in a rat sepsis model.

Disseminated intravascular coagulation is a disorder that affects the function of the clotting system and is frequently associated with sepsis or septic shock. One of its leading symptoms is the decrease in circulating fibrinogen.

Added 2 months ago

Treatment of refractory vasospastic angina complicated by acute pulmonary oedema with levosimendan: a case report.

Case summary: We present a case of recurrent episodes of VA complicated by acute pulmonary oedema and cardiogenic shock despite maximal tolerated therapy (intravenous calcium antagonist and nitrates) that was successfully...

Added 7 months ago

Management of cardiogenic shock in patients with acute coronary syndromes.

Cardiogenic shock remains a major problem affecting a large proportion of patients with acute coronary syndromes, with a persistent high mortality rate. Although mechanical reperfusion with percutaneous coronary intervention has improved...

Added 7 months ago

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Clinical trials

Effect of Albumin Administration on Vasopressor Duration in Resolving Septic Shock

The role of albumin in sepsis has been controversial for decades. Although hypoalbuminemia has been associated with worse outcomes in sepsis, definitive evidence does not exist that replacing albumin in these patients improves outcomes.

Added 11 months ago

Altering Sedation Paradigms to Improve Brain Injury and Survival in Severe Sepsis

Ventilated ICU patients frequently have sepsis and the majority have delirium, a form of brain dysfunction that is an independent predictor of increased risk of dying, length of stay, costs, and prolonged cognitive...

Added 2 years ago

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Alex Keen

Alex studied Biological Sciences at university before joining EPG Health in January 2017, where he works as a digital content manager and editor.

In his spare time, Alex enjoys relaxing with a cool pint in the company of good friends. 

ISICEM 2018 – The Sepsis Six and BUFALO

At nearly 30 million annual cases and 6 million deaths globally, sepsis is one of the world’s biggest killers. The Sepsis Six and BUFALO aim to speed up the time from sepsis diagnosis to effective treatment by using 6 simple steps, with the aim to improve outcomes across the globe. 


Sepsis case study

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