Latest news articles

Added 1 month ago Drug news

Positive phase III top-line results from CHIASMA OPTIMAL trial of Mycapssa for the maintenance treatment of adults with acromegaly

Chiasma, Inc. announced positive top-line data from the company’s pivotal Phase III CHIASMA OPTIMAL clinical trial evaluating its octreotide capsules...

Added 3 months ago Drug news

Phase III fliGHt trial shows TransCon Growth Hormone safe in pediatric growth hormone deficiency

Ascendis Pharma announced preliminary results from the phase III fliGHt Trial of TransCon Growth Hormone (hGH). The results indicated treatment...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Cushing's Syndrome

Cushing's Syndrome

Cushing’s syndrome shares symptoms such as hypertension, glucose intolerance and obesity with other common conditions – how can you confidently diagnose this rare disorder?

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Cardiovascular Metabolism Knowledge Centre

Cardiovascular Metabolism Knowledge Centre

The Cardiovascular Metabolism Knowledge Centre is an information hub providing expert insight into the management of hypertension and type 2 diabetes. This Knowledge Centre contains a wealth of scientific video content offering insights and opinion from some of the leading experts in the field.

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Guidelines

Hyperparathyroidism (primary): diagnosis, assessment and initial management

This guideline covers diagnosing, assessing and managing primary hyperparathyroidism. It aims to improve recognition and treatment of this condition, reducing long‑term complications and improving quality of life.

Added 1 month ago

Guidelines for the investigation of chronic diarrhoea in adults: British Society of Gastroenterology, 3rd edition

Chronic diarrhoea is a common problem, hence clear guidance on investigations is required. This is an updated guideline from 2003 for the investigations of chronic diarrhoea...

Added 1 year ago

Guidelines on Male Hypogonadism

Androgens play a crucial role in the development and maintenance of male reproductive and sexual functions. Low levels of circulating androgens can cause disturbances in male sexual development, resulting in congenital abnormalities...

Added 4 years ago

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Journal articles

Channelopathies.

Channelopathies are a heterogeneous group of disorders resulting from the dysfunction of ion channels located in the membranes of all cells and many cellular organelles. These include diseases of the nervous system (e.g., generalized epilepsy...

Added 1 month ago

The diagnostic accuracy of increased late night salivary cortisol for Cushing's syndrome: a real-life prospective study.

Introduction and aim: A prompt diagnosis of Cushing’s Syndrome (CS) in high-risk populations is mandatory: 1-mg dexamethasone suppression test (1-mg DST), late night salivary cortisol (LNSC), and urinary-free cortisol (UFC)...

Added 5 months ago

Diagnostic value of the late-night salivary cortisol in the diagnosis of clinical and subclinical Cushing's syndrome: results of a single-center 7-year experience.

Late-night salivary cortisol (LNSaC) is an easy-to-use test reflecting the free cortisol level in the serum and does not require hospitalization. Controlled studies reported that LNSaC has a high sensitivity and specificity...

Added 5 months ago

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Clinical trials

Pharmacokinetic (PK), Pharmacodynamic (PD) and Tolerability of Osilodrostat in Pediatric Patients With Cushing's Disease

Multicenter, open-label, non-comparative study to evaluate the pharmacokinetics, pharmacodynamics, and tolerability of osilodrostat in children and adolescent patients with Cushing's disease.

Added 2 months ago

Open-label Treatment in Cushing's Syndrome (OPTICS)

This is a long-term, OLE study of levoketoconazole in subjects with endogenous CS who have completed one or both parent studies or otherwise potentially qualify for this study, as defined in the eligibility criteria.

Added 2 months ago

Multicenter Study of Seliciclib (R-roscovitine) for Cushing Disease

This phase 2 multicenter, open-label clinical trial will evaluate safety and efficacy of 4 weeks of oral seliciclib in patients with newly diagnosed, persistent, or recurrent Cushing disease.

Added 2 months ago

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Monica Caliber

I am a medical writer with a Master Degree in Nutrition from the University of Stockholm and the Karolinska Institute, Sweden, and have done PhD level coursework at Baylor University, TX. USA. I specialize in preventive medicine and testosterone deficiency/treatment. Having lost my father ... Read more

Hypogonadism – why important to diagnose and treat?

Most clinicians and patients think that the purpose of treating hypogonadism is to merely relieve symptoms. However, this only scratches the surface... 

CME

Step by step: how to diagnose and manage type 1 diabetes in adults in primary care

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BMJ Learning - British Medical Learning
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Diabetic ketoacidosis in adults

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Clinical pointers: recognising and managing acute complications of diabetes in adults

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BMJ Learning - British Medical Learning
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