Latest news articles

Added 1 year ago Drug news

FDA approves ReCell System to treat burns.- AVITA Medical

AVITA Medical announced that the FDA approved the Company’s Premarket Approval (PMA) application to market the ReCell Autologous Cell Harvesting...

Added 1 year ago Drug news

CE Mark for CleanCision wound retraction and protection system.- Prescient Surgical,

Prescient Surgical announced it received CE Mark approval for its first-in-class, advanced technology CleanCision which fights and defends against the...

Added 1 year ago Drug news

FDA approves Catasyn Advanced Technology Wound Hydrogel to treat burns and wounds.- Synedgen.

Synedgen, a company leveraging its proprietary glycomics technology platform to develop glycopolymer-based therapeutics for infectious and inflammatory conditions, announced that...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Fibrinogen Deficiency in Bleeding

Fibrinogen Deficiency in Bleeding

Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.

Transplantation

Transplantation

See information on best practice in solid organ transplantation, and expert discussions on related hot topics.

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Guidelines

A practical guideline for the haematological management of major haemorrhage

The aim of these updated guidelines is to provide recommendations for the haematological management of major haemorrhage in any clinical situation...

Added 4 years ago

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Journal articles

Fibrin structure and wound healing.

Fibrinogen and fibrin play an important role in blood clotting, fibrinolysis, cellular and matrix interactions, inflammation, wound healing, angiogenesis, and neoplasia. The contribution of fibrin(ogen) to these processes largely...

Added 5 months ago

Assessing the Efficacy of Prothrombin Complex Concentrate in Multiply Injured Patients With High-Energy Pelvic and Extremity Fractures

The use of PCC for reversing coagulopathy in multiply injured patients with pelvic and/or lower extremity fractures remains unclear. This study assesses the efficacy of PCC for reversing coagulopathy in this group of patients.

Added 2 years ago

Prothrombin complex concentrate versus fresh-frozen plasma for reversal of coagulopathy of trauma: is there a difference?

This retrospective matched-cohort study compared fresh frozen plasma (FFP) alone with combination FFP and prothrombin complex concentrate (PCC) for reversing trauma induced coagulopathy. 

Added 2 years ago

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