Latest news articles

Added 2 months ago Drug news

OPTION trial initiated to compare WATCHMAN FLX left atrial appendage closure platform to first-line oral anticoagulants

Boston Scientific Corporation has initiated the OPTION trial to compare safety and effectiveness of the next-generation WATCHMAN FLX left atrial...

Added 5 months ago Drug news

Phase IIIb ELIMINATE-AF study of Lixiana shows safety and efficacy in bleeding events

Daiichi Sankyo announced results from phase IIIb ELIMINATE-AF, a prospective, randomised, open label, blinded endpoint evaluation (PROBE) design study assessing...

Added 5 months ago Drug news

Real-world study of Xarelto finds efficacy and cost saving in atrial fibrillation

The Janssen Pharmaceutical Companies of Johnson & Johnson announced results of a new real-world study, which found newly diagnosed patients...

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Learning Zones

An Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.



See information on best practice in solid organ transplantation, and expert discussions on related hot topics.

Fibrinogen Deficiency in Bleeding

Fibrinogen Deficiency in Bleeding

Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.

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Journal articles

Delays in the presentation to stroke services of patients with transient ischaemic attack and minor stroke.

The UK National Institute for Health and Care Excellence (NICE) guidelines state that carotid endarterectomy should be scheduled within 2 weeks of symptoms. The recent National Stroke Strategy has reduced the time interval to 48 h.

Added 2 years ago

Concomitant Use of Single Antiplatelet Therapy With Edoxaban or Warfarin in Patients With Atrial Fibrillation: Analysis From the ENGAGE AF-TIMI48 Trial.

Background: We studied the concomitant use of single antiplatelet therapy (SAPT) on the efficacy and safety of the anti-Xa agent...

Added 3 years ago

Experiences with TachoSil® in microneurosurgery.

Background: We analyze our experience of using TachoSil® (Takeda Austria GmbH: Linz, Austria) in microneurosurgical procedures as a hemostat and...

Added 3 years ago

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Stroke: clinical review

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