Intracranial (head) injuries are a common reason for presentation to emergency services. Globally, the scale is hard to quantify, with some estimations suggesting 42 million...
Added 1 year ago Drug news
GE Healthcare announces 510(k) clearance for its Signa Premier MRI system ,a new wide bore 3.0T magnetic resonance imaging (MRI)...
Added 5 years ago Drug news
Tissue Regeneration Systems has received 510(K) approval from the FDA for its Cranial Bone Void Filler product, indicated for use...
An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.
Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.
See information on best practice in solid organ transplantation, and expert discussions on related hot topics.
The Migraine Knowledge Centre features latest research on the prevalence and impact of migraine, the proposed neurological basis of the condition (and how this is being translated into new and exciting drug therapies), as well as current patient care strategies collated from headache organisations worldwide.
ESICM LIVES Congress 2018: Bringing you the latest news and insights from the 31st ESICM LIVES Congress, 20–24 October 2018 Paris, France.
Head injury: Triage, assessment, investigation and early management of head injury in children, young people and adults
This guideline covers the assessment and early management of head injury in children, young people and adults.
Added 5 years ago
Early recognition and intervention is essential for survival. The immediate priorities are to control bleeding (surgery and interventional radiology) and maintain vital organ perfusion by transfusing blood and other fluids through...
Added 21 days ago
This guideline provides recommendations on post-acute assessment for adults over 16 years of age with brain injuries and interventions for cognitive, communicative, emotional, behavioural and physical rehabilitation.
Added 6 years ago
Updated concepts on the pathophysiology and the clinical management of trauma hemorrhage and coagulopathy.
Uncontrolled hemorrhage and subsequent trauma-induced coagulopathy (TIC) are still the principle causes for preventable death after trauma and early detection and aggressive management have been associated with reduced mortality.
Added 29 days ago
Do we still need cryoprecipitate? Cryoprecipitate and fibrinogen concentrate as treatments for major hemorrhage - how do they compare?
This paper examines the current practice and evidence regarding the role of different modes of fibrinogen replacement in major hemorrhage in 3 distinct clinical settings: trauma, obstetric hemorrhage, and gastrointestinal...
Added 1 month ago
Spreading depression (SD) is a transient wave of near-complete neuronal and glial depolarization associated with massive transmembrane ionic and water shifts. It is evolutionarily conserved in the central nervous systems of...
Added 2 months ago
Randomized, controlled clinical trial evaluating the efficacy and safety of andexanet versus usual standard of care in patients with intracranial hemorrhage anticoagulated with a direct oral anticoagulant
Added 8 days ago
The purpose of this study is to try early injection of fibrinogen concentrate in severe isolated traumatic brain injury and investigation the effect of it on post bleeding and complications.
Added 1 month ago