Intracranial injury

Intracranial (head) injuries are a common reason for presentation to emergency services. Globally, the scale is hard to quantify, with some estimations suggesting 42 million


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Latest news articles

Added 2 years ago Drug news

FDA grants 510(k) approval for Signa Premier MRI system. GE HealthCare

GE Healthcare announces 510(k) clearance for its Signa Premier MRI system ,a new wide bore 3.0T magnetic resonance imaging (MRI)...

Added 6 years ago Drug news

FDA approves Cranial Bone Void Filler repair system

Tissue Regeneration Systems has received 510(K) approval from the FDA for its Cranial Bone Void Filler product, indicated for use...

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Learning Zones

An Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Fibrinogen Deficiency in Bleeding

Fibrinogen Deficiency in Bleeding

Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.



See information on best practice in solid organ transplantation, and expert discussions on related hot topics.

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Head injury: Triage, assessment, investigation and early management of head injury in children, young people and adults

This guideline covers the assessment and early management of head injury in children, young people and adults.

Added 5 years ago

Transfusion Handbook - 7.3: Transfusion management of major haemorrhage

Early recognition and intervention is essential for survival. The immediate priorities are to control bleeding (surgery and interventional radiology) and maintain vital organ perfusion by transfusing blood and other fluids through...

Added 5 months ago

Brain injury rehabilitation in adults

This guideline provides recommendations on post-acute assessment for adults over 16 years of age with brain injuries and interventions for cognitive, communicative, emotional, behavioural and physical rehabilitation.

Added 6 years ago

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Journal articles

Updated concepts on the pathophysiology and the clinical management of trauma hemorrhage and coagulopathy.

Uncontrolled hemorrhage and subsequent trauma-induced coagulopathy (TIC) are still the principle causes for preventable death after trauma and early detection and aggressive management have been associated with reduced mortality.

Added 5 months ago

Do we still need cryoprecipitate? Cryoprecipitate and fibrinogen concentrate as treatments for major hemorrhage - how do they compare?

This paper examines the current practice and evidence regarding the role of different modes of fibrinogen replacement in major hemorrhage in 3 distinct clinical settings: trauma, obstetric hemorrhage, and gastrointestinal...

Added 5 months ago

Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature.

Spreading depression (SD) is a transient wave of near-complete neuronal and glial depolarization associated with massive transmembrane ionic and water shifts. It is evolutionarily conserved in the central nervous systems of...

Added 7 months ago

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Clinical trials

Trial of Andexanet in ICH Patients Receiving an Oral FXa Inhibitor

Randomized, controlled clinical trial evaluating the efficacy and safety of andexanet versus usual standard of care in patients with intracranial hemorrhage anticoagulated with a direct oral anticoagulant

Added 4 months ago

Fibrinogen Concentrate in Isolated Traumatic Brain Injury

The purpose of this study is to try early injection of fibrinogen concentrate in severe isolated traumatic brain injury and investigation the effect of it on post bleeding and complications.

Added 5 months ago

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