Intracranial injury

Intracranial (head) injuries are a common reason for presentation to emergency services. Globally, the scale is hard to quantify, with some estimations suggesting 42 million


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Latest news articles

Added 2 years ago Drug news

FDA grants 510(k) approval for Signa Premier MRI system. GE HealthCare

GE Healthcare announces 510(k) clearance for its Signa Premier MRI system ,a new wide bore 3.0T magnetic resonance imaging (MRI)...

Added 6 years ago Drug news

FDA approves Cranial Bone Void Filler repair system

Tissue Regeneration Systems has received 510(K) approval from the FDA for its Cranial Bone Void Filler product, indicated for use...

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Learning Zones

An Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Fibrinogen Deficiency in Bleeding

Fibrinogen Deficiency in Bleeding

Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.



See information on best practice in solid organ transplantation, and expert discussions on related hot topics.

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Head injury: assessment and early management

This guideline covers the assessment and early management of head injury in children, young people and adults.

Added 5 years ago

The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition.

Background: Severe traumatic injury continues to present challenges to healthcare systems around the world, and post-traumatic bleeding remains a leading cause of potentially preventable death among injured patients.

Added 1 month ago

Transfusion Handbook - 7.3: Transfusion management of major haemorrhage

Early recognition and intervention is essential for survival. The immediate priorities are to control bleeding (surgery and interventional radiology) and maintain vital organ perfusion by transfusing blood and other fluids through...

Added 7 months ago

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Journal articles

Administration of fibrinogen concentrate in exsanguinating trauma patients is associated with improved survival at 6 hours but not at discharge.

Background: Despite poor evidence and high costs, fibrinogen concentrate (FC) represents one of the most frequently used hemostatic agents in exsanguinating trauma. The aim was to assess whether the administration of FC...

Added 1 month ago

Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy.

Introduction: Thromboelastometry (TEM)-guided haemostatic therapy with fibrinogen concentrate and prothrombin complex concentrate (PCC) in trauma patients may reduce the need for transfusion of red blood cells (RBC) or...

Added 1 month ago

Fibrinogen levels in trauma patients during the first seven days after fibrinogen concentrate therapy: a retrospective study.

Background: Fibrinogen concentrate (FC) is increasingly used as first line therapy in bleeding trauma patients. It remains unproven whether FC application increases post-traumatic plasma fibrinogen concentration (FIB) in injured...

Added 1 month ago

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Clinical trials

Trial of Andexanet in ICH Patients Receiving an Oral FXa Inhibitor

Randomized, controlled clinical trial evaluating the efficacy and safety of andexanet versus usual standard of care in patients with intracranial hemorrhage anticoagulated with a direct oral anticoagulant

Added 7 months ago

Fibrinogen Concentrate in Isolated Traumatic Brain Injury

The purpose of this study is to try early injection of fibrinogen concentrate in severe isolated traumatic brain injury and investigation the effect of it on post bleeding and complications.

Added 8 months ago

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