Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Fibrinogen Deficiency in Bleeding

Fibrinogen Deficiency in Bleeding

Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.

Transplantation

Transplantation

See information on best practice in solid organ transplantation, and expert discussions on related hot topics.

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Guidelines

The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition.

Background: Severe traumatic injury continues to present challenges to healthcare systems around the world, and post-traumatic bleeding remains a leading cause of potentially preventable death among injured patients.

Added 1 month ago

Guidelines on Urological Trauma

The European Association of Urology (EAU) Guidelines Group for Urological Trauma prepared these guidelines in order to assist medical professionals in the management of urological trauma in adults.

Added 3 years ago

2014 ESC Guidelines on the diagnosis and treatment of aortic diseases

Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult.

Added 5 years ago

Search all guidelines for Crushing or internal injury
 

Journal articles

Administration of fibrinogen concentrate in exsanguinating trauma patients is associated with improved survival at 6 hours but not at discharge.

Background: Despite poor evidence and high costs, fibrinogen concentrate (FC) represents one of the most frequently used hemostatic agents in exsanguinating trauma. The aim was to assess whether the administration of FC...

Added 1 month ago

Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy.

Introduction: Thromboelastometry (TEM)-guided haemostatic therapy with fibrinogen concentrate and prothrombin complex concentrate (PCC) in trauma patients may reduce the need for transfusion of red blood cells (RBC) or...

Added 1 month ago

Fibrinogen levels in trauma patients during the first seven days after fibrinogen concentrate therapy: a retrospective study.

Background: Fibrinogen concentrate (FC) is increasingly used as first line therapy in bleeding trauma patients. It remains unproven whether FC application increases post-traumatic plasma fibrinogen concentration (FIB) in injured...

Added 1 month ago

Search all journal articles for Crushing or internal injury
 
My Urology Doc

I am a general urologist and men's health expert in Indianapolis, Indiana, U.S.A. I'm also an avid blogger and heath innovator. My social media brand, My Urology Doc, aims to make the formerly taboo world of urology more fun and appealing.

Men's Health: A Forgotten Topic

Men's health is a forgotten topic. To be honest, we men are mostly to blame. We've clung to our masculine misconceptions and repeatedly refused to engage the healthcare community. Who can blame us, we're invincible and we're going to live forever, right? Well, not exactly. Let's look at some of the reasons men's health is one of the least engaged topics in healthcare.