Latest news articles

Added 17 days ago Drug news

MSC-100-IV rolling submission for acute graft versus host disease filed with FDA.

Mesoblast Limited announced that it has filed the first component of a rolling submission for a Biologics License Application (BLA)...

Added 19 days ago Drug news

Kalytera announces data elucidating CBD’s mechanisms of action in prevention of GVHD.

Kalytera Therapeutics, Inc. announced new laboratory findings demonstrating that cannabidiol (“CBD”) acts through a distinct biological pathway to restore epithelial...

Added 22 days ago Drug news

FDA approves Jakafi for the treatment of steroid-refractory acute graft versus host disease.

Incyte Corporation has announced that the FDA has approved Jakafi (ruxolitinib) for the treatment of steroid-refractory acute GVHD in adult...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Transplantation

Transplantation

See information on best practice in solid organ transplantation, and expert discussions on related hot topics.

Fibrinogen Deficiency in Bleeding

Fibrinogen Deficiency in Bleeding

Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.

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Guidelines

EASL Clinical Practice Guidelines: Liver transplantation

This Clinical Practice Guideline (CPG) has been developed to assist physicians and other healthcare providers during the evaluation process of candidates for LT and to help them in the correct management of patients after LT.

Added 3 years ago

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Journal articles

Faecal microbiota transplantation: a regulatory hurdle?

During faecal microbiota transplantation, stool from a healthy donor is transplanted to treat a variety of dysbiosis-associated gut diseases. Competent authorities are faced with the challenge to provide adequate regulation.

Added 1 month ago

Steatosis in Liver Transplantation: Current Limitations and Future Strategies.

This review focuses on the current and potential future treatment of NASH and the clinical practice in fatty liver transplantation, highlights its limitations and optimal allocation, and summarizes the advances of experimental...

Added 2 months ago

Bone marrow versus peripheral blood as a graft source for haploidentical donor transplantation in adults using post-transplant cyclophosphamide-A systematic review and meta-analysis.

Background: Peripheral-blood (PB) and bone marrow (BM) are both widely used in hematopoietic stem cell transplantation (HSCT). However, it is unclear whether PB or BM produces a more satisfactory outcome in haploidentical HSCT...

Added 2 months ago

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Clinical trials

Letermovir (MK-8228) Versus Placebo in the Prevention of Clinically-Significant Cytomegalovirus (CMV) Infection in Adult, CMV-Seropositive Allogeneic Hematopoietic Stem Cell Transplant Recipients (MK-8228-001)

The study evaluated the efficacy and safety of letermovir (MK-8228) for the prevention of clinically-significant CMV infection in adult, CMV-seropositive recipients of allogeneic hematopoietic stem cell transplant (HSCT).

Added 1 year ago

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Jonathan Macdonald

ECCMID 2018 ‒ Antibiotic resistance: an immediate and growing threat

This year’s ECCMID is hosting a large number of sessions discussing antibiotic resistance, an immediate and pressing issue that has been described as ‘one of the biggest threats to global health, food security, and development today'.

CME

Starting patients on anticoagulants in secondary care: how to do it

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Union of European Medical Specialists (via European Accreditation Council for CME)
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