Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Fibrinogen Deficiency in Bleeding

Fibrinogen Deficiency in Bleeding

Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.

Migraine Knowledge Centre

Migraine Knowledge Centre

The Migraine Knowledge Centre features latest research on the prevalence and impact of migraine, the proposed neurological basis of the condition (and how this is being translated into new and exciting drug therapies), as well as current patient care strategies collated from headache organisations worldwide.

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Guidelines

Intensive Care Society review of best practice for analgesia and sedation in the critical care.

This review has been prepared to assist the multidisciplinary Intensive Care (ICU) team determine the best sedative regimen for their patients.

Added 2 years ago

Search all guidelines for Coma, stupor and brain damage
 

Journal articles

Benzodiazepine-associated delirium in critically ill adults.

The association between benzodiazepine use and delirium risk in the ICU remains unclear.

Added 1 year ago

Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study.

To ascertain the relationship among early (first 48 h) deep sedation, time to extubation, delirium and long-term mortality.

Added 1 year ago

Early intensive care sedation predicts long-term mortality in ventilated critically ill patients.

Choice and intensity of early (first 48 h) sedation may affect short- and long-term outcome.

Added 1 year ago

Search all journal articles for Coma, stupor and brain damage
 

Clinical trials

Comparison of Propofol and Dexmedetomidine to Treat Hyperactive and Mixed ICU Delirium - the Basel ProDex Randomized Trial

In this randomized study, the investigators aim to test the hypothesis that the reinstitution of a normal circadian rhythm by continuous infusions of dexmedetomidine compared to propofol between 8pm and 6am...

Added 2 years ago

Bioavailability of Subcutaneously Given Dexmedetomidine in Healthy Volunteers

The aim of this study is to investigate the pharmacokinetics of subcutaneously administered dexmedetomidine in healthy volunteers. The absolute bioavailability of subcutaneously...

Added 2 years ago

Search all clinical trials for Coma, stupor and brain damage
 

CME

Loss of consciousness - red flag symptoms

Accrediting body
MIMS Learning - Monthly Index of Medical Specialities
Credits available
0
Registration required
0
Subscription fee
0

Delirium: clinical review

Accrediting body
MIMS Learning - Monthly Index of Medical Specialities
Credits available
2
Registration required
1
Subscription fee
0
Search all CME for Coma, stupor and brain damage