Latest news articles

Added 17 hours ago Drug news

FDA approves sBLA for Nplate in immune thrombocytopenia.- Amgen

Amgen announced that the FDA has approved Amgen's Supplemental Biologics License Application (sBLA) for Nplate (romiplostim) to include new data...

Added 10 days ago Drug news

FDA approves Wilate for haemophilia A.- Octapharma

Octapharma USA announced the FDA has approved Wilate for treatment of adults and adolescents with hemophilia A for routine prophylaxis...

Added 18 days ago Drug news

Swedish Orphan Biovitrum AB (publ) (Sobi) has entered into an expanded agreement with Sanofi to exercise early opt-in for the development and commercialisation of BIVV 001 for the treatment of hemophilia A.

Swedish Orphan Biovitrum AB (publ) (Sobi) has entered into an expanded agreement with Sanofi to exercise early opt-in for the...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Oral Anticoagulation Reversal

Oral Anticoagulation Reversal

Experts discuss the use of non-vitamin K oral anticoagulants in the treatment and prevention of stroke, deep vein thrombosis and pulmonary embolism in atrial fibrillation patients.

Chronic Lymphocytic Leukaemia (CLL)

Chronic Lymphocytic Leukaemia (CLL)

Refine your knowledge of chronic lymphocytic leukaemia (CLL) with information on pathophysiology, diagnosis, treatment options and more

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Guidelines

BSH Guideline: management of thrombotic and haemostatic issues in paediatric malignancy

Venous thromboembolism (VTE) and bleeding are serious complications of cancer and its treatment. A recent survey of UK paediatric haematologists and oncologists identified a broad variety of practice in the management of issues...

Added 1 year ago

Guidelines for the management of acute joint bleeds and chronic synovitis in haemophilia: A United Kingdom Haemophilia Centre Doctors' Organisation (UKHCDO) guideline.

Evidence-based guidelines were developed summarizing best practice for the assessment and management of acute joint bleeds and chronic synovitis in persons with haemophilia.

Added 1 year ago

Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology: First update 2016.

The management of perioperative bleeding involves multiple assessments and strategies to ensure appropriate patient care. Initially, it is important to identify those patients with an increased risk of perioperative bleeding.

Added 2 years ago

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Journal articles

Current Evidence for Pharmacologic Reversal Using Direct Oral Anticoagulants: What's New?

Direct oral anticoagulants are increasingly used in clinical practice and have addressed many of the issues related to vitamin K antagonists. However, the lack of reversal in life-threatening situations raises concerns regarding patient...

Added 19 days ago

Reversal agents for oral anticoagulant-associated major or life-threatening bleeding.

Oral anticoagulants (OA) are effective drugs for treating and preventing the formation of blood clots in patients with atrial fibrillation, mechanical heart valves and venous thromboembolism but their therapeutic effect is always counterbalanced...

Added 19 days ago

Reversal agents for direct oral anticoagulants: considerations for hospital physicians and intensivists.

Direct oral anticoagulants (DOACs) include dabigatran etexilate, a direct thrombin inhibitor, and specific inhibitors of activated coagulation factor X (FXa; e.g. apixaban, betrixaban, edoxaban, rivaroxaban).

Added 1 month ago

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Clinical trials

Pregnancy and Fibrinogen Disorders (FIBRINOGEST)

The aim of this observational study is to evaluate the prevalence of uncomplicated pregnancies in women suffering from congenital fibrinogen disorders (i.e, hypofibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia)...

Added 4 months ago

Efficacy, Safety, and Pharmacokinetic Study of Prophylactic Emicizumab Versus No Prophylaxis in Hemophilia A Participants (HAVEN 5)

This randomized, multicenter, open-label, Phase 3 study is designed to investigate the efficacy, safety, and pharmacokinetics of emicizumab in participants with hemophilia A regardless of factor VIII (FVIII) inhibitor status.

Added 1 year ago

Adjusted Fibrinogen Replacement Strategy (AdFIrst)

The purpose of this study is to investigate efficacy and safety of fibrinogen concentrate BT524, when administered to patients with major blood loss during elective spine surgery.The study aims to demonstrate that BT524 is at least...

Added 4 months ago

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CME

Dermatological emergencies in children

Accrediting body
MIMS Learning - Monthly Index of Medical Specialities
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Survival guide: safe prescribing for surgical inpatients

Accrediting body
Union of European Medical Specialists (via European Accreditation Council for CME)
Credits available
1
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1
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90

Starting patients on oral anticoagulants in primary care: how to do it

Accrediting body
Union of European Medical Specialists (via European Accreditation Council for CME)
Credits available
1
Registration required
1
Subscription fee
90
Search all CME for Coagulation and haemorrhagic disorders