Latest news articles

Added 10 days ago Drug news

Elocta and Alprolix can provide perioperative haemostatic control across a wide spectrum of surgeries

Sobi and Sanofi will present data demonstrating that Elocta (efmoroctocog alfa) and Alprolix (eftrenonacog alfa) can provide perioperative haemostatic control...

Added 22 days ago Drug news

CHMP recommends Doptelet to treat severe thrombocytopenia in adult patients with chronic liver disease

The Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending the granting of a marketing authorisation...

Added 24 days ago Drug news

CHMP recommends approval of Esperoct in haemophilia A

Novo Nordisk announced that the Committee for Medicinal Products for Human Use (CHMP), under the European Medicines Agency (EMA), adopted a positive opinion for the use of Esperoct...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Oral Anticoagulation Reversal

Oral Anticoagulation Reversal

Experts discuss the use of non-vitamin K oral anticoagulants in the treatment and prevention of stroke, deep vein thrombosis and pulmonary embolism in atrial fibrillation patients.

Chronic Lymphocytic Leukaemia (CLL)

Chronic Lymphocytic Leukaemia (CLL)

Refine your knowledge of chronic lymphocytic leukaemia (CLL) with information on pathophysiology, diagnosis, treatment options and more

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Guidelines

BSH Guideline: management of thrombotic and haemostatic issues in paediatric malignancy

Venous thromboembolism (VTE) and bleeding are serious complications of cancer and its treatment. A recent survey of UK paediatric haematologists and oncologists identified a broad variety of practice in the management of issues...

Added 1 year ago

Guidelines for the management of acute joint bleeds and chronic synovitis in haemophilia: A United Kingdom Haemophilia Centre Doctors' Organisation (UKHCDO) guideline.

Evidence-based guidelines were developed summarizing best practice for the assessment and management of acute joint bleeds and chronic synovitis in persons with haemophilia.

Added 11 months ago

A practical guideline for the haematological management of major haemorrhage

The aim of these updated guidelines is to provide recommendations for the haematological management of major haemorrhage in any clinical situation...

Added 3 years ago

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Journal articles

Fibrinolysis and the control of blood coagulation.

Fibrin plays an essential role in hemostasis as both the primary product of the coagulation cascade and the ultimate substrate for fibrinolysis. Fibrinolysis efficiency is greatly influenced by clot structure, fibrinogen isoforms and...

Added 9 hours ago

Genetics, diagnosis and clinical features of congenital hypodysfibrinogenemia: a systematic literature review and report of a novel mutation.

Background: Hypodysfibrinogenemia is a rare disease characterized by decreased levels of a dysfunctional fibrinogen. It shares features with both hypo‐ and dysfibrinogenemia, although with specific molecular patterns and...

Added 10 hours ago

Clinical Features and Management of Congenital Fibrinogen Deficiencies.

Congenital fibrinogen disorders are rare diseases affecting either the quantity (afibrinogenemia and hypofibrinogenemia) or the quality (dysfibrinogenemia) or both (hypodysfibrinogenemia) of plasmatic fibrinogen.

Added 10 hours ago

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Clinical trials

Efficacy, Safety, and Pharmacokinetic Study of Prophylactic Emicizumab Versus No Prophylaxis in Hemophilia A Participants (HAVEN 5)

This randomized, multicenter, open-label, Phase 3 study is designed to investigate the efficacy, safety, and pharmacokinetics of emicizumab in participants with hemophilia A regardless of factor VIII (FVIII) inhibitor status.

Added 1 year ago

FIBrinogen REplenishment in Surgery (FIBRES)

This is a pragmatic, prospective, multi-center, randomized, active-control, single-blinded, non-inferiority phase 3 trial in adult cardiac surgical patients. Up to 12 Canadian hospitals will participate, and the trial will require up to 2 years...

Added 8 days ago

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Emicizumab Given Every 4 Weeks in Participants With Hemophilia A (HAVEN 4)

This multicenter, open-label, non-randomized study will assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of emicizumab administered at a dose of 6 milligrams per kilogram (mg/kg) every 4 weeks...

Added 1 year ago

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CME

Dermatological emergencies in children

Accrediting body
MIMS Learning - Monthly Index of Medical Specialities
Credits available
1
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1
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0

Survival guide: safe prescribing for surgical inpatients

Accrediting body
Union of European Medical Specialists (via European Accreditation Council for CME)
Credits available
1
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1
Subscription fee
90

Starting patients on oral anticoagulants in primary care: how to do it

Accrediting body
Union of European Medical Specialists (via European Accreditation Council for CME)
Credits available
1
Registration required
1
Subscription fee
90
Search all CME for Coagulation and haemorrhagic disorders