Latest news articles

Added 13 days ago Drug news

BioMarin Pharma hassubmitted a MAA to the European Medicines Agency for valoctocogene roxaparvovec for adults with severe hemophilia A.

BioMarin Pharmaceutical Inc. has announced that the company submitted a Marketing Authorization Application (MAA) to the European Medicines Agency (EMA)...

Added 1 month ago Drug news

FDA approves sBLA for Nplate in immune thrombocytopenia.- Amgen

Amgen announced that the FDA has approved Amgen's Supplemental Biologics License Application (sBLA) for Nplate (romiplostim) to include new data...

Added 1 month ago Drug news

FDA approves Wilate for haemophilia A.- Octapharma

Octapharma USA announced the FDA has approved Wilate for treatment of adults and adolescents with hemophilia A for routine prophylaxis...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Oral Anticoagulation Reversal

Oral Anticoagulation Reversal

Experts discuss the use of non-vitamin K oral anticoagulants in the treatment and prevention of stroke, deep vein thrombosis and pulmonary embolism in atrial fibrillation patients.

Chronic Lymphocytic Leukaemia (CLL)

Chronic Lymphocytic Leukaemia (CLL)

Refine your knowledge of chronic lymphocytic leukaemia (CLL) with information on pathophysiology, diagnosis, treatment options and more

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Guidelines

BSH Guideline: management of thrombotic and haemostatic issues in paediatric malignancy

Venous thromboembolism (VTE) and bleeding are serious complications of cancer and its treatment. A recent survey of UK paediatric haematologists and oncologists identified a broad variety of practice in the management of issues...

Added 1 year ago

Guidelines for the management of acute joint bleeds and chronic synovitis in haemophilia: A United Kingdom Haemophilia Centre Doctors' Organisation (UKHCDO) guideline.

Evidence-based guidelines were developed summarizing best practice for the assessment and management of acute joint bleeds and chronic synovitis in persons with haemophilia.

Added 1 year ago

Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology: First update 2016.

The management of perioperative bleeding involves multiple assessments and strategies to ensure appropriate patient care. Initially, it is important to identify those patients with an increased risk of perioperative bleeding.

Added 2 years ago

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Journal articles

Effect of Fibrinogen Concentrate vs Cryoprecipitate on Blood Component Transfusion After Cardiac Surgery: The FIBRES Randomized Clinical Trial.

Objective: To determine if fibrinogen concentrate is noninferior to cryoprecipitate for treatment of bleeding related to hypofibrinogenemia after cardiac surgery.

Added 13 days ago

Fibrinogen concentrates in hereditary fibrinogen disorders: Past, present and future.

Hereditary fibrinogen disorders (HFD) are rare coagulation disorders. Even if the spectrum of symptoms is broad depending on the sub‐type, bleeding is the most common complication.

Added 13 days ago

Antidotes for reversal of direct oral anticoagulants.

The main advantage of the direct oral anticoagulants over vitamin K antagonists is reduced rates of major bleeding, especially intracranial hemorrhage. While use of different clotting factor supplements have been used in patients with...

Added 14 days ago

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Clinical trials

Pregnancy and Fibrinogen Disorders (FIBRINOGEST)

The aim of this observational study is to evaluate the prevalence of uncomplicated pregnancies in women suffering from congenital fibrinogen disorders (i.e, hypofibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia)...

Added 5 months ago

Efficacy, Safety, and Pharmacokinetic Study of Prophylactic Emicizumab Versus No Prophylaxis in Hemophilia A Participants (HAVEN 5)

This randomized, multicenter, open-label, Phase 3 study is designed to investigate the efficacy, safety, and pharmacokinetics of emicizumab in participants with hemophilia A regardless of factor VIII (FVIII) inhibitor status.

Added 1 year ago

Adjusted Fibrinogen Replacement Strategy (AdFIrst)

The purpose of this study is to investigate efficacy and safety of fibrinogen concentrate BT524, when administered to patients with major blood loss during elective spine surgery.The study aims to demonstrate that BT524 is at least...

Added 5 months ago

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CME

Dermatological emergencies in children

Accrediting body
MIMS Learning - Monthly Index of Medical Specialities
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Survival guide: safe prescribing for surgical inpatients

Accrediting body
Union of European Medical Specialists (via European Accreditation Council for CME)
Credits available
1
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1
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90

Starting patients on oral anticoagulants in primary care: how to do it

Accrediting body
Union of European Medical Specialists (via European Accreditation Council for CME)
Credits available
1
Registration required
1
Subscription fee
90
Search all CME for Coagulation and haemorrhagic disorders