Latest news articles

Added 1 month ago Drug news

Braftovi triplet combination success in BEACON CRC trial in patients with BRAFV600E-mutant metastatic colorectal cancer

Array BioPharma Inc. announced positive results from the interim analysis of the Phase III BEACON CRC trial evaluating the combination...

Added 1 month ago Drug news

Study of Signatera ctDNA assay in colorectal cancer published in JAMA Oncology

A new clinical study shows that Natera's Signatera ctDNA assay identified colorectal cancer recurrence up to 16.5 months earlier than...

Added 1 month ago Drug news

Tecentriq and Cotellic combination fails Phase III trial to treat microsatellite-stable colorectal cancer

Tecentriq and Cotellic combination failed to improve survival over standard third-line therapy for patients with chemorefractory metastatic colorectal cancer (CRC)...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Transplantation

Transplantation

See information on best practice in solid organ transplantation, and expert discussions on related hot topics.

Fibrinogen Deficiency in Bleeding

Fibrinogen Deficiency in Bleeding

Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.

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Guidelines

Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Evidence shows that rectal cancer is distinct from colon cancer, with different aetiologies and risk factors possibly reflecting different environmental exposures.

Added 6 years ago

Diagnosis and management of colorectal cancer

This guideline covers diagnosis and treatment of colorectal cancer. It summarises the evidence and, where appropriate, provides evidence-based recommendations...

Added 7 years ago

Colorectal cancer: diagnosis and management

This guideline covers diagnosing and managing colorectal (bowel) cancer in people aged 18 and over.

Added 7 years ago

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Journal articles

Advances in organ preserving strategies in rectal cancer patients.

Treatment of rectal cancer patients has been subjected to change over the past thirty years. Total mesorectal excision is considered the cornerstone of rectal cancer treatment, but is also associated with significant morbidity resulting in...

Added 1 year ago

Quality of life in a randomized trial of early closure of temporary ileostomy after rectal resection for cancer (EASY trial).

Background: A temporary ileostomy may reduce symptoms from anastomotic leakage after rectal cancer resection. Earlier results of the EASY trial showed that early closure of the temporary ileostomy was associated with...

Added 1 year ago

Individual surgeon is an independent risk factor for leak after double-stapled colorectal anastomosis: An institutional analysis of 800 patients.

Background: Our aim was to assess whether the individual surgeon is an independent risk factor for anastomotic leak in double-stapled colorectal anastomosis after left colon and rectal cancer resection.

Added 1 year ago

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Clinical trials

Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab With a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients With BRAF V600E-mutant Metastatic Colorectal Cancer (BEACON CRC)

This is a multicenter, randomized, open-label, 3-arm Phase 3 study to evaluate encorafenib + cetuximab plus or minus binimetinib versus Investigator's choice of either irinotecan/cetuximab or FOLFIRI/cetuximab...

Added 11 months ago

A Phase I Study of Bavituximab, Capecitabine, and Radiation for the Treatment of Rectal Adenocarcinoma

This is a phase I study incorporating bavituximab into the care of patients with rectal adenocarcinoma simultaneously treated with capecitabine and radiation therapy. There is no reference therapy as we are trying to identify...

Added 2 years ago

Reolysin in Combination With FOLFOX6 and Bevacizumab or FOLFOX6 and Bevacizumab Alone in Metastatic Colorectal Cancer

The purpose of this study is to find out if giving reolysin in combination with FOLFOX6/ bevacizumab can offer better results than standard therapy with FOLFOX6/ bevacizumab.

Added 2 years ago

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Fiona Holland

Fiona worked in the fitness and wellness industry in the US for 13 years, supporting behaviour change in a variety of settings. Fiona’s research interests lie broadly within health and wellbeing. She is particularly interested in qualitative methodologies in the areas of body image ... Read more

What to say and do when someone has cancer

Ahead of World Cancer Day on Saturday (February 4), Fiona Holland, Psychology Lecturer, discusses what to say and what not to say to someone with cancer.

CME

Association of adherence to lifestyle recommendations and risk of colorectal cancer: a prospective Danish cohort study

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Union of European Medical Specialists (via European Accreditation Council for CME)
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Carcinoma of unknown primary origin: diagnosis and management: putting NICE guidelines into practice

Accrediting body
Union of European Medical Specialists (via European Accreditation Council for CME)
Credits available
1
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90
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