Cancer of breast

Breast cancer is the second most commonly diagnosed cancer worldwide, behind only lung cancers; this is even more remarkable when its relative rarity in males is noted (males


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Latest news articles

Added 7 days ago Drug news

Seattle Genetics initiates phase III trial ( HER2CLIMB-02) of tucatinib + ado-trastuzumab emtansine to treat metastatic HER2-positive (HER2+) breast cancer.

Seattle Genetics, Inc. announced dosing of the first patient in HER2CLIMB-02, a randomized phase III clinical trial evaluating investigational agent...

Added 17 days ago Drug news

Verzenio (abemaciclib) significantly extends life by a median of 9.4 months for women with HR+, HER2- advanced breast cancer in MONARCH 2 study.- Eli Lilly

Eli Lilly and Company announced Verzenio (abemaciclib) in combination with fulvestrant significantly extended life by a median of 9.4 months...

Added 20 days ago Drug news

Patient shows significant response in early study of Bria-IMT + Keytruda for breast cancer.- BriaCell

BriaCell Therapeutics has announced clinical updates of its Phase I/IIa clinical trial of Bria-IMT immunotherapy in a combination Study with...

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Learning Zones

An Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

CDK 4/6 inhibitors in metastatic breast cancer

CDK 4/6 inhibitors in metastatic breast cancer

The CDK 4/6 Inhibitors in Metastatic Breast Cancer Learning Zone provides insights and information for metastatic breast cancer (mBC) and CDK 4/6 signalling. This includes the burden and pathophysiology of the disease, the role of CDK 4/6 in cell proliferation and an overview of the CDK 4/6 inhibitors that have been approved for the management of mBC.



See information on best practice in solid organ transplantation, and expert discussions on related hot topics.

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Early Breast Cancer: ESMO Clinical Practice Guidelines

These updated ESMO Clinical Practice Guidelines provide updated state-of-the-art recommendations on management of early breast cancer (diagnosis, treatment and follow-up), compiled by a multidisciplinary author panel...

Added 2 months ago

4th ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4)

The ESO-ESMO 4th international consensus guidelines for advanced breast cancer (ABC 4) focus on methodology, assessment guidelines and treatment recommendations for specific breast cancer subtypes...

Added 1 year ago

Advanced breast cancer: diagnosis and treatment

This guideline covers care and support for people with advanced (stage 4) breast cancer.

Added 10 years ago

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Journal articles

Neoadjuvant Talazoparib for Patients With Operable Breast Cancer With a Germline BRCA Pathogenic Variant.

Purpose: Talazoparib has demonstrated efficacy in patients with BRCA-positive metastatic breast cancer. This study evaluated the pathologic response of talazoparib alone for 6 months in patients with a known germline BRCA...

Added 28 days ago

Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation.

Background: The poly(adenosine diphosphate-ribose) inhibitor talazoparib has shown antitumor activity in patients with advanced breast cancer and germline mutations in BRCA1 and BRCA2 ( BRCA1/2).

Added 28 days ago

Advances in the use of PARP inhibitors for BRCA1/2-associated breast cancer: talazoparib.

Poly-ADP-ribosyl polymerase (PARP) enzymes PARP-1 and PARP-2 recognize DNA damage and set off a cascade of cellular mechanisms required for multiple types of DNA damage repair. PARP inhibitors are small molecule...

Added 1 month ago

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Clinical trials

Study of IMMU-132 in HR+/HER2- MBC (TROPICS-02)

This is an open-label, randomized, multicenter Phase 3 study to compare the efficacy and safety of Sacituzumab Govitecan versus TPC in subjects with metastatic or locally recurrent inoperable HR+/HER2- MBC, after failure of...

Added 2 months ago

A Study To Evaluate the Efficacy and Safety Of Atezolizumab or Placebo in Combination With Neoadjuvant Doxorubicin + Cyclophosphamide Followed By Paclitaxel + Trastuzumab + Pertuzumab In Early Her2-Positive Breast Cancer (IMpassion050)

This study (also known as IMpassion050) will evaluate the efficacy and safety of atezolizumab compared with placebo when given in combination with neoadjuvant dose-dense anthracycline (doxorubicin) + cyclophosphamide followed...

Added 2 months ago

Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04]

Brief Summary:
This study will compare DS-8201a to physician choice standard treatment.
Participants must have HER2-low breast cancer that has been treated before.

Added 2 months ago

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Advances in Precision Cancer Care

Advances in Precision Cancer Care aims to bring you the latest news and some of the most exciting developments in precision cancer care.

Our first reports come from ESMO Congress 2018.

ESMO 2018 | Day 2 highlights

Saturday’s ESMO 2018 report comes from Presidential Symposium 1, moderated by Andrés Cervantes (Valencia, ES) and Josep Tabernero (Barcelona, ES), discussing the scientific results and clinical implications of new data from the phase 3 IMpassion130, PALOMA-3 and SOLAR-1 trials. 


Carcinoma of unknown primary origin: diagnosis and management: putting NICE guidelines into practice

Accrediting body
Union of European Medical Specialists (via European Accreditation Council for CME)
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