Cancer of breast

Breast cancer is the second most commonly diagnosed cancer worldwide, behind only lung cancers; this is even more remarkable when its relative rarity in males is noted (males

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Latest news articles

Added 13 days ago Drug news

HLX 02 trastuzumab biosimilar is filed at EMA

Shanghai Henlius Biotech announced on 21 June 2019 that the regulatory submission for its proposed trastuzumab biosimilar (HLX 02) had...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

CDK 4/6 inhibitors in metastatic breast cancer

CDK 4/6 inhibitors in metastatic breast cancer

The CDK 4/6 Inhibitors in Metastatic Breast Cancer Learning Zone provides insights and information for metastatic breast cancer (mBC) and CDK 4/6 signalling. This includes the burden and pathophysiology of the disease, the role of CDK 4/6 in cell proliferation and an overview of the CDK 4/6 inhibitors that have been approved for the management of mBC.

Transplantation

Transplantation

See information on best practice in solid organ transplantation, and expert discussions on related hot topics.

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Guidelines

Early Breast Cancer: ESMO Clinical Practice Guidelines

These updated ESMO Clinical Practice Guidelines provide updated state-of-the-art recommendations on management of early breast cancer (diagnosis, treatment and follow-up), compiled by a multidisciplinary author panel...

Added 23 days ago

4th ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4)

The ESO-ESMO 4th international consensus guidelines for advanced breast cancer (ABC 4) focus on methodology, assessment guidelines and treatment recommendations for specific breast cancer subtypes...

Added 1 year ago

Advanced breast cancer: diagnosis and treatment

This guideline covers care and support for people with advanced (stage 4) breast cancer.

Added 10 years ago

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Journal articles

Phase III Randomized Study of Ribociclib and Fulvestrant in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: MONALEESA-3.

This phase III study evaluated ribociclib plus fulvestrant in patients with hormone receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer who were treatment naïve or had received...

Added 1 year ago

Synergistic antitumor activity by combining trastuzumab with retinoic acid in HER2 positive human breast cancer cells.

Breast cancer can be classified into molecular subtypes. Tumors overexpressing HER2 protein are more aggressive and metastatic; hence, patients have a poor prognosis.

Added 1 year ago

Trastuzumab-induced cardiotoxicity and its risk factors in real-world setting of breast cancer patients.

The aim of this retrospective study was to determine the frequency and timing of trastuzumab cardiotoxicity and its risk factors in real-world setting.

Added 1 year ago

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Clinical trials

Study of IMMU-132 in HR+/HER2- MBC (TROPICS-02)

This is an open-label, randomized, multicenter Phase 3 study to compare the efficacy and safety of Sacituzumab Govitecan versus TPC in subjects with metastatic or locally recurrent inoperable HR+/HER2- MBC, after failure of...

Added 30 days ago

A Study To Evaluate the Efficacy and Safety Of Atezolizumab or Placebo in Combination With Neoadjuvant Doxorubicin + Cyclophosphamide Followed By Paclitaxel + Trastuzumab + Pertuzumab In Early Her2-Positive Breast Cancer (IMpassion050)

This study (also known as IMpassion050) will evaluate the efficacy and safety of atezolizumab compared with placebo when given in combination with neoadjuvant dose-dense anthracycline (doxorubicin) + cyclophosphamide followed...

Added 30 days ago

Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04]

Brief Summary:
This study will compare DS-8201a to physician choice standard treatment.
Participants must have HER2-low breast cancer that has been treated before.

Added 30 days ago

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Advances in Precision Cancer Care

Advances in Precision Cancer Care aims to bring you the latest news and some of the most exciting developments in precision cancer care.

Our first reports come from ESMO Congress 2018.

ESMO 2018 | Day 2 highlights

Saturday’s ESMO 2018 report comes from Presidential Symposium 1, moderated by Andrés Cervantes (Valencia, ES) and Josep Tabernero (Barcelona, ES), discussing the scientific results and clinical implications of new data from the phase 3 IMpassion130, PALOMA-3 and SOLAR-1 trials. 

CME

Carcinoma of unknown primary origin: diagnosis and management: putting NICE guidelines into practice

Accrediting body
Union of European Medical Specialists (via European Accreditation Council for CME)
Credits available
1
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1
Subscription fee
90
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