Latest news articles

Added 3 months ago Drug news

New England Journal of Medicine publishes roxadustat China phase III results for the treatment of anemia in chronic kidney disease patients receiving dialysis

FibroGen, Inc. announced the publication of clinical study results in the New England Journal of Medicine (NEJM)1 from the China...

Added 3 months ago Drug news

Roxadustat China phase III trial for treatment of anemia in chronic kidney disease patients not on dialysis published in the NEJM

FibroGen, Inc. announced publication of results from the Phase III trial of the efficacy and safety of roxadustat treatment compared...

Added 6 months ago Drug news

Pooled cardiovascular safety analyses of the global Phase III programme for roxadustat

AstraZeneca has announced top-line results from the pooled cardiovascular (CV) safety analyses of the global Phase III programme for roxadustat...

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Learning Zones

An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.

Fibrinogen Deficiency in Bleeding

Fibrinogen Deficiency in Bleeding

Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. This learning zone looks at both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger level for treatment and treatment options.

Transplantation

Transplantation

See information on best practice in solid organ transplantation, and expert discussions on related hot topics.

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Journal articles

Benzodiazepine-associated delirium in critically ill adults.

The association between benzodiazepine use and delirium risk in the ICU remains unclear.

Added 2 years ago

Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study.

To ascertain the relationship among early (first 48 h) deep sedation, time to extubation, delirium and long-term mortality.

Added 2 years ago

Early intensive care sedation predicts long-term mortality in ventilated critically ill patients.

Choice and intensity of early (first 48 h) sedation may affect short- and long-term outcome.

Added 2 years ago

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Heavy menstrual bleeding in primary care: putting NICE guidelines into practice

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