Albumin use in decompensated cirrhosis

European Association for the Study of the Liver (EASL) clinical practice guidelines on the management of decompensated cirrhosis, including ascites, spontaneous bacterial peritonitis (SBP), and hepatorenal syndrome in cirrhosis are available (European Association for the Study of the Liver, 2018).

The progression from compensated to decompensated cirrhosis is marked by numerous overt clinical signs such as ascites, bleeding, encephalopathy, and jaundice. The progression of the disease and the associated complications can reduce median survival from 12 years to approximately 2 years. The need for effective management of these symptoms has led the European Association for the Study of the Liver to publish their first Clinical Practice Guidelines for the management of decompensated cirrhosis. The recommendation of albumin infusion is seen across the guidelines for a number of the complications discussed. This infographic highlights the role of albumin has in managing the signs and symptoms of decompensated cirrhosis.

EASL clinical practice guidelines for the management of patients with decompensated cirrhosis Download a PDF version here.

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Publications (27)
  • Hydroxyethyl starch solutions and patient harm

    Following the European Medicines Agency’s (EMA) suspension of the marketing authorisations of hydroxyethyl starch (HES) solutions across the European Union (EMA, 2018), Roberts et al., have written an open letter addressed to the World Health Organization (WHO) Director General seeking support for the suspension of HES solutions and expanding it to a worldwide ban.

  • Recruitment of extravascular fluid by hyperoncotic albumin

    In 1896 Ernest Starling published his hypothesis for fluid exchange, whereby fluid exchange exists mainly in the capillaries through a process of plasma ultrafiltration across semipermeable membranes (Starling, 1896). But is this 19th century theory something of the past?

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