Fibrinogen Deficiency

Fibrinogen is important for blood clot formation and breakdown. It is the first coagulant factor to be reduced to critical levels during massive trauma, cardiac surgery and postpartum haemorrhage that involve excessive bleeding. Persistent fibrinogen deficiency can lead to bleeding complications and an increased risk in mortality. Early identification and treatment of fibrinogen deficiency could therefore save lives.

Correct perioperative management of fibrinogen loss experienced during heart surgery and postpartum haemorrhage is key to treatment success.

Fibrinogen role in haemostasis

Fibrinogen role in haemostasis<br></br>

Fibrinogen plays a structural role in blood clot formation and paradoxically, is involved in regulating blood clot lysis.

Congenital fibrinogen deficiency

Congenital fibrinogen deficiency

A plethora of mutations have been identified in the three genes that encode fibrinogen, impacting on either the quality or quantity of fibrinogen produced.

Acquired fibrinogen deficiency

Acquired fibrinogen deficiency<br></br>

Dilutional or consumptive coagulopathy and blood loss can lead to fibrinogen deficiency during trauma, cardiac surgery and postpartum haemorrhage.

This section firstly explains the role for fibrinogen in haemostasis. It then highlights both congenital and acquired fibrinogen deficiencies such as dilutional and consumptive coagulopathy and loss during massive trauma, cardiac surgery and postpartum haemorrhage.

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