Fibrinogen is an essential coagulation factor in the blood clotting cascade. The importance for fibrinogen in normal haemostasis is highlighted in patients of inherited fibrinogen deficiencies who display coagulopathies such as excessive bleeding and thrombolytic events.
Fibrinogen deficiency is a clinical challenge for bleeding management. We discuss both congenital and acquired fibrinogen deficiencies.
Read about techniques used in the clinic to measure the quantity and quality of fibrinogen and the available data on point–of–care devices.
Here we compare fibrinogen concentrate with fresh frozen plasma and cryoprecipitate for treating fibrinogen deficiencies in different clinical contexts.
In this learning zone, we highlight that acquired fibrinogen deficiencies are much more common than congenital deficiencies. Acquired fibrinogen deficiency is usually the result of consumption, dilution or loss through bleeding as occurs during massive trauma, cardiac surgery and postpartum haemorrhage. Learn more about both congenital and acquired fibrinogen deficiencies including indications and techniques for diagnosis, trigger levels for treatment and treatment options.