Adrenocortical carcinoma 

Adrenocortical carcinoma (ACC) is a rare, aggressive endocrine malignancy arising from the adrenal cortex. It is a progressive disease associated with a poor prognosis. Most of patients (~2/3) symptoms are due to signs of hormone excess. Hypercortisolism is the most common case (50%–80%) which gives rise to rapidly developing Cushing’s syndrome (Else et al., 2014). This learning resource will enable you to understand the symptoms of ACC, and the key recommendations for clinical assessment, detailed hormonal work-up, imaging, pathological work-up, and staging classification and prognostic factors.

What is ACC?

Discover the key features of ACC, by watching the 2-minute animation below, which includes an introduction to the diagnosis and treatment recommendations associated with this disease.


Disease Overview

What is adrenocortical carcinoma? View the key facts, clinical presentation and prognosis.

ESE Diagnosis Recommendations

This section details the key recommendations of the European Society of Endocrinology (ESE).

ESE Treatment Recommendations

Review treatment recommendations are based on whether ACC is localised or advanced.


Associations, societies and patient support groups to help further your knowledge and understanding of adrenocortical carcinoma.


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