• Cushing’s Syndrome

    What is Cushing’s Syndrome, how does it present, what is its pathophysiology and how do I recognise it in my patients? 

  • Diagnosis

    Learn about the numerous tests that exist to help diagnose Cushing's, elucidating its specific cause so that it can be effectively treated.

  • Disease Management

    Whar are the latest guideline recommendations for Cushing's syndrome? What treatments are available to target different causes of the disease?

  • Congress & Symposia

    Explore a wide range of congress and symposia, held across the globe, that cover rare disease and endocrinological disorders. 

  • Resources

    Find out more information surrounding Cushing's from scientific societies and organisations that could be of help to you and your patients. 

 

Cushing's Syndrome Knowledge Centre

Cushing’s Syndrome is a rare disease which is the physiological consequence of an excess of cortisol, either released from an endocrine tumour or from exogenous sources. In this educational resource, you will discover the symptoms of Cushing's syndrome in adults and find a detailed description of the pathophysiology and its resultant impact on morbidity and mortality.

Within the Disease Overview section, details of: the history of Cushing's; its prevalence; the HPA axis, interactions between the hypothalamus, pituitary and adrenal glands;  ACTH-independent Cushing's; and its wide range of presentations and symptoms, such as hypertension, rounded face, thick skin and nephrolithiasis. The Diagnosis section provides details of several diagnostic methods, such as the 24-hour urinary free cortisol test, late-night salivary cortisol test, overnight dexamethasone suppression test and desmopressin test, as well as information on differential diagnoses to help find the cause of the disease. Discover what the ultimate expectations and goals are from treatment, the different comorbidities, current guidelines, transsphenoidal surgery, radiotherapy, bilateral adrenalectomy, pharmacological interventions and future treatments in the Disease Management section. 

Cushing's Syndrome case studies illustrate potential treatment pathways, along with guidance on diagnosis and disease management. 

  • Ashley Grossman Biography

    All content has been reviewed and supported by Professor Ashley Grossman. View his biography and disclosures here.

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    Overview

    Overview

    Read about the epidemiology, pathophysiology and symptoms of Cushing's Syndrome. What role does cortisol play, who does it disproportionately affect and what is hirsutism?

    Diagnosis

    Diagnosis

    Discover how initial diagnosis of Cushing's Syndrome is followed up by a differential diagnosis to identify the cause of a patient's excessive cortisol level.

    Management

    Management

    Find out more about the wide array of treatments available for Cushing's Syndrome, such as adrenal steroidogenesis inhibitors and glucocorticoid receptor blockers. What are the guidelines recommendations?

    Case Studies

    Case Studies

    Consider the appropriate diagnostic and treatment approach to a selection of case studies, and compare your responses with Professor Grossman's recommendations.

    Congresses and Symposia

    Congresses and Symposia

    Consult our upcoming events calendar to view key information about endocrinology and rare disease congress and symposia worldwide.

    Resources

    Resources

    Further your knowledge and understanding of Cushing's Syndrome by visiting these useful external websites, for both you and your patients.

     

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