Cushing’s Syndrome is a rare disease which is the physiological consequence of an excess of cortisol, either released from an endocrine tumour or from exogenous sources. In this educational resource, you will discover the symptoms of Cushing's syndrome in adults and find a detailed description of the pathophysiology and its resultant impact on morbidity and mortality.
Within the Disease Overview section, details of: the history of Cushing's; its prevalence; the HPA axis, interactions between the hypothalamus, pituitary and adrenal glands; ACTH-independent Cushing's; and its wide range of presentations and symptoms, such as hypertension, rounded face, thick skin and nephrolithiasis. The Diagnosis section provides details of several diagnostic methods, such as the 24-hour urinary free cortisol test, late-night salivary cortisol test, overnight dexamethasone suppression test and desmopressin test, as well as information on differential diagnoses to help find the cause of the disease. Discover what the ultimate expectations and goals are from treatment, the different comorbidities, current guidelines, transsphenoidal surgery, radiotherapy, bilateral adrenalectomy, pharmacological interventions and future treatments in the Disease Management section.
Cushing's Syndrome case studies illustrate potential treatment pathways, along with guidance on diagnosis and disease management.
Read about the epidemiology, pathophysiology and symptoms of Cushing's Syndrome. What role does cortisol play, who does it disproportionately affect and what is hirsutism?
Discover how initial diagnosis of Cushing's Syndrome is followed up by a differential diagnosis to identify the cause of a patient's excessive cortisol level.
Find out more about the wide array of treatments available for Cushing's Syndrome, such as adrenal steroidogenesis inhibitors and glucocorticoid receptor blockers. What are the guidelines recommendations?
Consider the appropriate diagnostic and treatment approach to a selection of case studies, and compare your responses with Professor Grossman's recommendations.
Consult our upcoming events calendar to view key information about endocrinology and rare disease congress and symposia worldwide.
Further your knowledge and understanding of Cushing's Syndrome by visiting these useful external websites, for both you and your patients.