Hypersensitivity reaction caused by specific immunological mechanisms. Hypersensitivity describes the onset of objectively reproducible signs and symptoms after exposure to specific stimuli at doses usually tolerated by the population.1,2


The system of immune responses that target “self”. Patients with autoimmune CSU typically produce IgE to autoallergens, IgG anti-IgE or IgG anti-FcεRI (the high-affinity IgE receptor).3


Disease characterised by the sudden appearance of wheals, angioedema, or both, that can be caused by allergic, autoimmune or other pathogenic causes.4
Acute urticaria: lasts <6 weeks
Chronic urticaria: lasts ≥6 weeks

1. Johansson SG et al. J Allergy Clin Immunol 2003; 113(5):832–6. 2. Pawankar R et al. World Allergy Organization, White Book on Allergy, 2011. 3. Kolkhir P et al. J Allergy Clin Immunol 2017; 139(6):1772–81. 4. Zuberbier T et al. Allergy 2018 Jul;73(7):1398–414.



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