Glossary

Allergy:

Hypersensitivity reaction caused by specific immunological mechanisms. Hypersensitivity describes the onset of objectively reproducible signs and symptoms after exposure to specific stimuli at doses usually tolerated by the population.1,2

Autoimmunity:

The system of immune responses that target “self”. Patients with autoimmune CSU typically produce IgE to autoallergens, IgG anti-IgE or IgG anti-FcεRI (the high-affinity IgE receptor).3

Urticaria:

Disease characterised by the sudden appearance of wheals, angioedema, or both, that can be caused by allergic, autoimmune or other pathogenic causes.4
Acute urticaria: lasts <6 weeks
Chronic urticaria: lasts ≥6 weeks

1. Johansson SG et al. J Allergy Clin Immunol 2003; 113(5):832–6. 2. Pawankar R et al. World Allergy Organization, White Book on Allergy, 2011. 3. Kolkhir P et al. J Allergy Clin Immunol 2017; 139(6):1772–81. 4. Zuberbier T et al. Allergy 2018 Jul;73(7):1398–414.

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