Symptoms References

  1. Global initiative for chronic Obstructive Lung Disease (GOLD 2017). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Available from:
  2. Eisner MD, Iribarren C, Yelin EH, et al. Pulmonary function and the risk of functional limitation in chronic obstructive pulmonary disease. Am J Epidemiol 2008;167:1090–1101.
  3. van der Molen T, Miravitlles M, Kocks JW. COPD management: role of symptom assessment in routine clinical practice. Int J Chron Obstruct Pulmon Dis 2013;8:461–471.
  4. Parada A, Klaassen J, Lisboa C, et al. [Reduction of physical activity in patients with chronic obstructive pulmonary disease]. Rev Med Chil 2011;139:15621572.
  5. Benzo RP, Chang CC, Farrell MH, et al. Physical activity, health status and risk of hospitalization in patients with severe chronic obstructive pulmonary disease. Respiration 2010;80:1018.
  6. Agusti A et al. Respir Res 2010;11:122.
  7. Reardon JZ et al. Am J Med 2006;119:32–37.
  8. Gysels M, Higginson IJ. Access to services for patients with chronic obstructive pulmonary disease: the invisibility of breathlessness. J Pain Symptom Manage 2008;36:451–460.
  9. ZuWallack R. How are you doing? What are you doing? Differing perspectives in the assessment of individuals with COPD. COPD 2007;4:293–7.
  10. Partridge MR, Karlsson N, Small IR. Patient insight into the impact of chronic obstructive pulmonary disease in the morning: an internet survey. Curr Med Res Opin 2009;25:20432048. 
  11. Partridge MR et al. Curr Med Res Opin 2012;28:1405. [Erratum].
  12. Kuyucu T, Guclu SZ, Saylan B, et al. A cross-sectional observational study to investigate daily symptom variability, effects of symptom on morning activities and therapeutic expectations of patients and physicians in COPD-SUNRISE study. Tuberk Toraks 2011;59:328339.
  13. Espinosa de los Monteros MJ, Pena C, Soto Hurtado EJ, et al. Variability of respiratory symptoms in severe COPD. Arch Bronconeumol 2012;48:37.
  14. O'Hagan P, Chavannes NH. The impact of morning symptoms on daily activities in chronic obstructive pulmonary disease. Curr Med Res Opin 2014;30:301314
  15. O’Donnell D. Impacting patient-centred outcomes in COPD: breathlessness and exercise tolerance. Eur Respir Rev 2006;15:42–46.
  16. Rennard S, Decramer M, Calverley PM, et al. Impact of COPD in North America and Europe in 2000: subjects’ perspective of confronting COPD International Survey. Eur Respir J 2002;20:799–805.
  17. Cleland JA, Lee AJ, Hall S. Associations of depression and anxiety with gender, age, health-related quality of life and symptoms in primary care COPD patients. Fam Pract 2007;24:217–223.
  18. Barnett M. Chronic obstructive pulmonary disease: a phenomenological study of patients’ experiences. J Clin Nurs 2005;14:805–812.
  19. Tsiligianni IG, van der Molen T, Moraitaki D, et al. Assessing health status in COPD. A head-to-head comparison between the COPD assessment test (CAT) and the clinical COPD questionnaire (CCQ). BMC Pulm Med 2012;12:20.
  20. Wedzicha JA, Seemungal TA. COPD exacerbations: defining their cause and prevention. Lancet 2007;370:786–796.
  21. Jones PW, Quirk FH, Baveystock CM. The St George's Respiratory Questionnaire. Respir Med 1991;85 Suppl B:2531.
  22. Westwood M, Bourbeau J, Jones PW, et al. Relationship between FEV1 change and patient-reported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic review. Respir Res 2011;12:40.