CDK 4/6 pathway

Increased cellular proliferation and dysregulation of the cell cycle is one of the hallmarks of cancer. In this section of the Learning Zone, we explore the role of CDK4/6 in the cell cycle and its role in normal and malignant breast tissue. You can also learn more about the pharmacological targeting of CDKs and their development in recent years.

Choose one of the subsections below, or scroll down the page, to learn more.

CDK 4/6 and cell proliferation

CDK 4/6 and cell proliferation

What is the role of CDK4/6 in the cell cycle and how is it involved in malignant transformation?

CDK 4/6 Inhibition

CDK 4/6 Inhibition

Several CDK4/6 inhibitors are now available or in development, but the development of CDK inhibitors hasn’t always been straightforward…