Increased cellular proliferation and dysregulation of the cell cycle is one of the hallmarks of cancer. In this section of the Learning Zone, we explore the role of CDK4/6 in the cell cycle and its role in normal and malignant breast tissue. You can also learn more about the pharmacological targeting of CDKs and their development in recent years.
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What is the role of CDK4/6 in the cell cycle and how is it involved in malignant transformation?
Several CDK4/6 inhibitors are now available or in development, but the development of CDK inhibitors hasn’t always been straightforward…