Ten Years of Vildagliptin

The DPP-4 inhibitors have become a standard of care for the management of type 2 diabetes, frequently used as a second-line treatment after metformin failure or first-line treatment in those patients who are intolerant to metformin. Vildagliptin was one of the first DPP-4 inhibitors, and 2017 marked 10 years since its launch. The following publications explore the role of vildagliptin in type 2 diabetes management and discuss the clinical and real-world data that are now available.

Ten years of vildagliptin – Professor Stefano Del Prato

Professor Stefano Del Prato outlines how DPP-4 inhibitors function and introduces the VERIFY and INTERVAL trials that are exploring the use of vildagliptin in early diagnosed- and elderly patients respectively. 

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The vildagliptin experience – 25 years since the initiation of the Novartis glucagon-like peptide-1 based therapy programme and 10 years since the first vildagliptin registration – Dr James E Foley and Professor Bo Ahrén

This review explores the discovery and clinical development of vildagliptin over the past 25 years.

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Dipeptidyl peptidase-4 inhibitor development and post-authorisation programme for vildagliptin – clinical evidence for optimised management of chronic diseases beyond Type 2 Diabetes – Dr Willian D Strain and Dr Päivi M Paldánius

Over the past decade, DPP-4 inhibitors have significantly changed the type 2 diabetes treatment paradigm, with a shift in focus to treating the underlying pathophysiology of the condition. This review explores the changing diabetes landscape and rise of different patient populations and the implications this has on management and health economics.

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Clinical safety and tolerability of vildagliptin – insights from randomised trials, observational studies and post-marketing surveillance – Professor Chantal Mathieu et al.

Vildagliptin has been extensively studied over the years. This review looks at the cumulative evidence for the safety and tolerability of vildagliptin from clinical development to real-world data.

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