• HPP is a rare, inherited metabolic disorder that occurs in patients of all ages and affects multiple organ systems
  • Early and accurate diagnosis of HPP is critical to avoid inappropriate management and worsening of clinical outcomes
  • ALP is a key diagnostic marker for HPP, and the presence of low ALP activity alongside clinical signs and symptoms of HPP is sufficient for its diagnosis
  • Appropriate age- and gender-adjusted paediatric reference ranges are critical for HPP diagnosis
    • Normal ALP activity varies with age and gender, and the lower limit of normal ALP activity is significantly higher in infants than in adults
  • Lab specialists can play an important role in the timely and accurate diagnosis of HPP by ensuring the use of appropriate ALP activity reference ranges and by flagging low ALP activity

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