Making the diagnosis of HPP

Low ALP activity levels can differentiate HPP from other skeletal disorders such as osteogenesis imperfecta and nutritional rickets that may have similar clinical signs (Linglart and Biosse-Duplan 2016; Rockman-Greenberg 2013). Accurate detection of low ALP levels can therefore play a key role in the differential diagnosis of HPP.

A table showing laboratory profiles in bone disorders

Following an HPP diagnosis, laboratory specialists may want to inform the patient, and their treating practitioners, of the importance of liaising with specialist reference centres and HPP patient support groups. By utilising these services, patients will benefit from coordinated HPP management and will gain a better understanding of the disease, receiving up-to-date, accurate information regarding HPP and its management (Bloch-Zupan 2016; Saraff 2016)

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