IMUNOVIR, Inosine pranobex - genital herpes, White to off-white tablets wit, Medicine and Disease information

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IMUNOVIR overview

Imunovir tablets are indicated in the management of: a) Mucocutaneous infections due to herpes simplex virus (type 1 and/or type II). b) Genital warts as adjunctive therapy to podophyllin or carbon dioxide laser. c) Subacute sclerosing panencephalitis (SSPE).

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Related DrugsDrug Details

IMUNOVIR

Drug Class Description :

Antivirals.

Generic Name :

Inosine pranobex - genital herpes

Drug description :

Each tablet contains 500mg Inosine Acedoben Dimepranol (INN, also known as inosine pranobex*) which is the p-acetamidobenzoic acid salt of N,N-dimethylamino-2-propanol [DIP.PAcBA] and ?-inosine in a 3:1 molar ratio. *British Approved Name (BAN) the non-proprietary designation

Presentation :

White to off-white tablets with a faint amine odour, engraved with a score-line on one side and 'DN' on the other. The score-line is only to facilitate breaking for ease of swallowing and not to divide into equal doses.

Indications :

Adult Dosage :

Adults:

Mucocutaneous herpes simplex: 1 g q.d.s. (4g daily), for 7 -14 days.

Genital warts: 1g t.d.s. (3g daily), for 14-28 days as adjunctive therapy to podophyllin or carbon dioxide laser.

Subacute sclerosing panencephalitis (SSPE): 50-100mg/kg daily, in divided does every 4 hours.

Children:

No information is available in children.

Elderly:

No dosage alterations are necessary in the elderly.

Child Dosage :

Not recommended.

Contra Indications :

There are no known contraindications to therapy with this drug.

Special Precautions :

As the inosine component of Imunovir is metabolised to uric acid, it should be used with caution in patients with renal impairment, a history of gout or hyperuricaemia

Adverse Reactions :

The only consistently observed drug-related side effect is a transient elevation (usually remaining within normal range) of urine and serum uric acid levels, which usually return to baseline values a few days after the end of treatment.

Side effects recorded in>1% of clinical studies of 3 months or longer and reported infrequently in postmarketing surveillance:

Gastrointestinal	Nausea with or without vomiting, epigastric discomfort
Hepatic	Elevation of transaminases, alkaline phosphatase or blood urea nitrogen (BUN) level
Dermatological	Itching, skin rashes
Nervous system	Headaches, vertigo, fatigue or malaise
Other	Arthralgia

Side effects recorded in <1% of clinical studies of 3 months or longer and reported rarely in postmarketing surveillance:

Gastrointestinal	Diarrhoea, constipation
Nervous system	Nervousness, drowsiness or insomnia
Genitourinary:	Polyuria (increased urine volume).

Manufacturer :

Newport Pharmaceuticals Limited

Drug Availability :

(POM)

Drug Updated :

20 May 2009

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