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| Drug class description : | Taxoids (antineoplastic agents). |
| Generic Name : | Docetaxel |
| Drug description : | Solution in vials plus diluent. |
| Presentation : | Infusion, docetaxel 20 mg , 80 mg . |
| Indications : | Locally advanced or metastatic breast cancer resistant or refractory to cytotoxic therapy that should have included an anthracycline. Locally advanced or metastatic non-small cell lung cancer resistant to chemotherapy. |
| Adult Dosage : | Breast cancer: 100 mg/m2 by intravenous infusion over 1 hour every 3 weeks. Non-small cell lung cancer: 75mg/ m2 by intravenous infusion over 1 hour every three weeks. If patient develops febrile or severe neutropenia, severe cutaneous reaction or severe peripheral neuropathy reduce subsequent dose to 75 mg/m 2, and if symptoms persist to 55 mg/m2 in subsequent cycles or discontinue. Pretreat patient with dexamethasone 8 mg twice daily dexamethasone 8 mg twice daily for 3 days starting 1 day prior to treatment. |
| Child Dosage : | Not recommended. |
| Contra Indications : | Previous severe hypersensitivity to docetaxel. Neutrophils <1.5 x 109/L, severe liver impairment. Pregnancy; contraception must be used for at least 3 months after therapy. Lactation. |
| Special Precautions : | Monitor blood counts; reduce subsequent doses if severe neutropenia ( <0.5 x 109/L for 7 days or more). Monitor patient during infusion for hypersensitivity and fluid retention. Perform liver function tests. |
| Interactions : | Cyclosporin, terfenadine, ketoconazole, erythromycin, troleandomycin. |
| Adverse Reactions : | Neutropenia, thrombocytopenia, anaemia, hypersensitivity reactions, cutaneous reactions, fluid retention, peripheral neuropathy, mucositis, arthralgia, myalgia, increase in liver enzymes. |
| Manufacturer : | Aventis |
| Drug Availability : | (POM) |
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