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| Drug class description : | Glycopeptides. |
| Generic Name : | Teicoplanin |
| Drug description : | Powder in vials. |
| Presentation : | Powder for injection, teicoplanin 200 mg , 400 mg . |
| Indications : | Potentially serious Gram-positive infections. Serious staphylococcal infections in patients sensitive or unresponsive to penicillins and cephalosporins. Effectiveness has been documented in the following infections: skin and soft tissue infections, urinary tract infections, lower respiratory tract infections, joint and bone infections, septicaemia, endocarditis and CAPD releated peritonitis. Prophylaxis in orthopaedic surgery at risk of Gram-positive infections. Species usually sensitive: Staphylococcus aureus and coagulase-negative staphylococci (sensitive or resistant to methicillin), streptococci, enterococci, Listeria monocytogenes, micrococci, Eikenella corrodens, group JK corynebacteria and Gram-positive corynebacteria and Gram-positive anaerobes including Clostridium difficile, and peptococci. |
| Adult Dosage : | Moderate infections: 400 mg intravenously or intramuscularly as a single dose on first day, then 200 mg intravenously or intramuscularly daily. Severe infections: 400 mg intravenously every 12 hours for three doses, then 400 mg intravenously or intramuscularly daily. Over 85 kg body-weight 3 - 6 mg/kg, see data sheet. Reduce dose from fourth day in renal insufficiency. See data sheet. CAPD peritonitis, see data sheet. Prophylaxis in orthopaedic surgery: 400 mg intravenously as a single dose at induction of anaesthesia. |
| Child Dosage : | Neonates, 16 mg/kg body-weight as a single dose by intravenous infusion over 30 minutes on first day, then 8 mg/kg body-weight as single daily dose; over 2 months, moderate infections, 10 mg/kg body-weight by intraveous injection every 12 hours for first three doses, then 6 mg/kg by intravenous or intramuscular injection as a single dose daily. Severe infections, 10 mg/kg body- weight by intravenous injection every 12 hours for first three doses, then 10 mg/kg by intravenous or intramuscular injection as a single dose daily. |
| Contra Indications : | Pregnancy, lactation. |
| Special Precautions : | Hypersensitivity to vancomycin. Perform regular haematological, liver, renal and auditory tests; see data sheet. |
| Adverse Reactions : | Local reactions at injection site, thrombophlebitis, rash, fever, bronchospasm, anaphylaxis, rigor, angioedema, exfoliative dermatitis, erythema multiforme, GI upset, dizziness, vestibular disorders, mild hearing loss, tinnitus, headache. Blood dyscrasias. Increase in serum transaminases, alkaline phosphatase and creatinine, renal failure. |
| Manufacturer : | Aventis |
| Drug Availability : | (POM) |
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