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| Drug class description : | Cardioselective b-blockers (beta- blockers) / calcium-channel blockers (class II calcium antagonists). |
| Generic Name : | Atenolol, nifedipine - angina |
| Drug description : | Reddish brown capsules marked with TENIF and 'S' logo. |
| Presentation : | Capsules, atenolol 50mg, sustained-release nifedipine 20mg. |
| Indications : | Angina prophylaxis, where a beta- blocker or calcium antagonist blocker or calcium antagonist proves inadequate. |
| Adult Dosage : | 1 twice daily. |
| Child Dosage : | Not recommended. |
| Contra Indications : | Bradycardia, uncontrolled heart failure, 2nd or 3rd degree heart block, cardiogenic shock. Pregnancy, lactation. Known hypersensitivity to either component, hypotension, metabolic acidosis, severe peripheral arterial circulatory disturbances, sick sinus syndrome, untreated phaeochromocytoma, severe renal impairment, aortic stenosis, unstable angina or during or within one month of a myocardial infarction, acute attacks of angina. |
| Special Precautions : | Cardiac conduction defects or poor cardiac reserve, COAD, renal or hepatic impairment, diabetes, anaesthesia, asthma. May be used with care in patients already treated with a beta-blocker and/ or whose signs of heart failure have been controlled. Thyrotoxicosis. Prinzmetal's angina. Atopy, asthenic symptoms, cerebrovascular insufficiency, first degree heart block. |
| Interactions : | Quinidine, cardiodepressants, rifampicin, clonidine withdrawal, disopyramide, verapamil, diltiazem, digoxin, hypoglycaemic agents, cimetidine, grapefruit juice, anaesthetics, adrenaline, ibuprofen, indomethacin. Nifedipine may cause falsely increased spectrophotometric values of urinary vanillylmandelic acid; measurement with HPLC is unaffected. |
| Adverse Reactions : | Flushing, headache, dizziness, dry eyes, skin rash, oedema, hypersensitivity type jaundice, gingival hyperplasia, purpura. Reports of impaired sperm function in single cases of in vitro fertilisation due to nifedipine (see SPC for further information). Also, confusion, agranulocytosis, urticaria, exanthema, dermatitis, systemic allergic reactions. Gastrointestinal disturbances, fatigue, bradycardia, heart failure deterioration, postural hypotension, cold extremities, precipitation of heart block, intermittent claudication, Raynaud's phenomenon, mood changes, nightmares, psychoses and hallucinations, sleep disturbances, dry mouth, elevations of transaminase levels, hepatic toxicity, alopecia, psoriaform skin reactions, exacerbations of psoriasis, paraesthesia, bronchospasm, visual disturbances, palpitations, tachycardia, gravitational oedema, disturbances of liver function, pruritus, erythromelalgia, myalgia, tremor, gynaecomastia, increased frequency of micturition, exacerbation of angina pectoris. |
| Manufacturer : | AstraZeneca |
| Drug Availability : | (POM) |
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