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| Drug class description : | Cardioselective b-blockers (beta- blockers) / thiazide-related diuretics (thiazides). |
| Generic Name : | Atenolol, chlortalidone [chlorthalidone] [co-tenidone] |
| Drug description : | Brown f-c tablets marked TENORET 50 and S. |
| Presentation : | Tablets, atenolol 50mg, chlortalidone 12.5mg. |
| Indications : | Hypertension, particularly in the elderly. |
| Adult Dosage : | 1 daily. |
| Child Dosage : | Not recommended. |
| Contra Indications : | 2nd or 3rd degree AV block, sinus bradycardia, sick sinus syndrome, severe peripheral arterial disease, uncompensated cardiac failure, cardiogenic shock, hypotension, untreated phaechromocytoma, metabolic acidosis. Pregnancy, lactation. Hypersensitivity to either component. Anuria, severe or progressive renal failure, metabolic acidosis. |
| Special Precautions : | Poor cardiac reserve should be controlled with digitalis and diuretics. History of bronchospasm (cardio-selective b- blockers usually have a lesser effect on airways resistance than the non-selective type but their use should also be avoided in patients with wheezing or obstructive airways disease unless there are compelling clinical reasons). Diabetes; metabolic acidosis. Asthenic symptoms. Cerebrovascular insufficiency. Renal or hepatic impairment, thyrotoxic crisis. General anaesthesia; consider withdrawal before elective surgery. Withdraw gradually. Gout, diabetes, hyperlipidaemia. Monitor electrolyte levels; thiazide diuretics can cause hypokalaemia so K+-supplements may be required. Prinzmetal's angina, first degree heart block, less severe peripheral arterial disease, ischaemic heart disease. |
| Interactions : | Clonidine withdrawal, verapamil, diltiazem, class I antiarrhythmics, class II calcium-channel blockers, cardiac depressant anaesthetics, hypoglycaemics, reserpine, other antihypertensives, ergot alkaloids, cimetidine, rifampicin, theophylline, warfarin, CNS depressants, sympathomimetics, indometacin (indomethacin), ibuprofen. Lithium, NSAIDs, digitalis, allopurinol, amantadine. Fatigue, hyperuricaemia, hypokalaemia, impaired glucose tolerance, hyponatraemia, dry mouth, nausea, leucopenia, skin rashes, alopecia, cold extremities, sleep disturbances, bradycardia, bronchospasm, heart failure deterioration, postural hypotension, GI upset. Gout, photosensitivity. Precipitation of heart block, intermittent claudication, Raynaud's phenomenon, confusion, dizziness, headache, mood changes, nightmares, psychoses and hallucinations, hepatic toxicity, purpura, thrombocytopenia, exacerbations of psoriasis, psoriaform skin reactions, visual disturbances. |
| Manufacturer : | AstraZeneca |
| Drug Availability : | (POM) |
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