Medical NewsGerman Drug Data (Deutsch)
Norwegian Drug Data (Norge)
Netherlands Drug Data (Nederlands)
Swedish Drug Data (Sverige)
Want to submit or suggest content for the epgonline.org YouTube Clinical channel?
Contact us here
epgonline.org is not responsible for content on any 3rd party website
Please register to access disease diagnosis, patient management, physician tools.
By viewing the content of this web page you are both confirming your status as a healthcare professional and agreeing to our terms of use.
| Drug class description : | Immunosuppressants. |
| Generic Name : | Cyclosporin - rheumatoid arthritis Imtix Sangstat has withdrawn SangCyA from the UK market. It remains available on a named patient basis for patients who were receiving the product before it was withdrawn in July 2000. |
| Drug description : | Solution for oral administration. |
| Presentation : | Oral solution, cyclosporin Ph Eur 100mg per mL. |
| Indications : | Treatment of severe, active rheumatoid arthritis in patients in whom classical, slow-acting antirheumatic agents are inappropriate or ineffective. |
| Adult Dosage : | 2.5mg/kg daily given orally in two divided doses for the first six weeks, increased gradually to a maximum of 4mg/kg/day. Discontinue if inadequate response after three months. See Summary of Product Characteristics. If converting patients from other proprietary oral formulations of cyclosporin, refer to SPC. |
| Child Dosage : | Not recommended. See Summary of Product Characteristics. Product Characteristics. |
| Contra Indications : | Known hypersensitivity to cyclosporin or to one of the excipients. Abnormal renal function, uncontrolled hypertension, uncontrolled infections or any kind of malignancy. Children under 18 years. Lactation. |
| Special Precautions : | May impair renal function; monitor serum creatinine at two- weekly intervals during first three months of treatment, and four-weekly thereafter. May affect liver function; monitor bilirubin and hepatic enzymes. Monitor serum potassium. Hyperuricaemia. Monitor blood pressure regularly - discontinue treatment if hypertension develops that cannot be controlled. Monitor blood lipid levels. Caution if using in combination with NSAIDs. See Summary of Product Characteristics. Pregnancy. |
| Interactions : | Systemic antibiotics or other compounds known to have nephrotoxic effects, eg, amphotericin B, aminoglycosides, ciprofloxacin, melphalan, trimethoprim. Ketoconazole, erythromycin, oral contraceptives, danazol, some calcium channel blockers including diltiazem, nicardipine and verapamil. Doxycycline, fluconazole, itraconazole, propafenone, lipid solutions. Phenytoin, carbamazepine, barbiturates, rifampicin. Sulphadiazine. Intravenous sulphadimidine. Prednisolone, methylprednisolone. NSAIDs. Lovastatin. Colchicine. Nifedipine. Potassium supplements, potassium-sparing diuretics. Grapefruit juice. Live attenuated vaccines. |
| Adverse Reactions : | Reversible and dose-dependent increase in serum creatinine and urea. Renal structural changes. Hypertrichosis, tremor, hyperrension, hepatic dysfunction, fatigue, gingival hypertrophy, gastrointestinal sensations of the hands and feet. Occasionally, headaches, rash, mild anaemia, hyperkalaemia, hyperuricaemia, gout, hypomagnesaemia, hypercholesterolaemia, weight increase, oedema, pancreatitis, neuropathy, confusion, paraesthesia, convulsions, reversible dysmenorrhoea or amenorrhoea may develop. Muscle weakness, muscle cramps and myopathy. Rarely, a syndrome of thrombocytopenia, sometimes in combination with microangiopathic haemolytic anaemia and renal failure has been observed. Rarely, gynaecomastia. |
| Manufacturer : | Imtix Sangstat |
| Drug Availability : | (POM) |
Only registered users have access to the full EPG Online Knowledge Base including drug search tools, interactive disease Knowledge Centres via the EPG Knowledge Library - with clinical and evidence based physician and research tools, MiMedia (build your own clinical media collection with everything from key opinion leader essays to mode of action videos and other multi-media content), the EPG Survey panel, health news updates and much much more.
Already Registered?
Please log-in now using our member login box.
Not a member?
Don't worry, registration is quick and FREE! We welcome all Healthcare professionals, doctors, nurses and medical students.
Register today to have full access to a wealth of drug data, educational and evidence based interactive guides across all major therapeutic areas, disease management, and clinical tools.
As a practicing Healthcare professional, you can also opt-in to join our market research panel – www.epgsurvey.com – and get paid for sharing your expert clinical opinions!
REGISTER today it only takes a minute! and it's FREE
Having problems?
Use our forgotten password facility or email us at: contact@epgonline.org