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| Drug class description : | Monoclonal antibodies (selective immunosuppressants). |
| Generic Name : | Infliximab - Crohn's disease |
| Drug description : | Powder for concentrate for solution for infusion. |
| Presentation : | Powder, infliximab 100mg. |
| Indications : | Treatment of severe active Crohn's disease in patients unresponsive to a full and adequate course of corticosteroid and/or immunosuppressant therapy; treatment of fistulising Crohn's disease, in patients unresponsive to a full and adequate course of therapy with conventional treatment. Also indicated in rheumatoid arthritis. |
| Adult Dosage : | Severe, active Crohn's disease: 5mg/kg by intravenous infusion over two hours. Fistulising Crohn's disease: initially 5mg/kg by intravenous infusion over two hours repeated after two weeks and six weeks. Repeat if necessary 14 weeks after last infusion. |
| Child Dosage : | Children under 17 years, not recommended. recommended. |
| Contra Indications : | Sepsis or clinically manifest infections and/or abscesses. History of hypersensitivity to infliximab, to other murine proteins or to any of the excipients. Pregnancy or lactation within six months of dose (ensure adequate contraception). |
| Special Precautions : | Monitor closely for acute infusion reactions within two hours of dose; if necessary slow rate, interrupt infusion or discontinue. Ensure emergency treatment is available. Monitor for delayed hypersensitivity if patient retreated after prolonged period. Discontinue if lupus-like symptoms appear or if antinuclear antibodies are detected. Elderly, hepatic or renal impairment. |
| Adverse Reactions : | Viral infection, fever. Headache, vertigo, dizziness. Hypertension, flushing. UTIs. Upper and lower respiratory tract infection, dyspnoea, sinusitis. GI upset. Skin reactions. Fatigue, chest pain. |
| Manufacturer : | Schering-Plough |
| Drug Availability : | (POM) |
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